Results 51 to 60 of about 1,164,710 (315)

Implications of avoiding overlap between training and testing data sets when evaluating genomic predictions of genetic merit [PDF]

, 2010
The aim of this study was to evaluate and quantify the importance of avoiding overlap between training and testing subsets of data when evaluating the effectiveness of predictions of genetic merit based on genetic markers.
G. Banos, Amer, P. R., P.R. Amer, Banos, G.   +3 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Environmental coupling of selection and heritability limits evolution

, 2006
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable ...
T H Clutton-Brock, D W Coltman, Pemberton J. M, Coltman, D. W., J. G. Pilkington, A. J. Wilson, Pemberton, J. M., D. W. Coltman, J G Pilkington, L E B Kruuk, Mifsud, D. V., Coltman D. W, J. M. Pemberton, D V Mifsud, D. V. Mifsud, Clutton-Brock T. H, Pilkington, J. G., Pilkington J. G, Wilson, A. J., Kruuk, L. E. B., A J Wilson, L. E. B. Kruuk, Clutton-Brock, T. H., T. H. Clutton-brock, Wilson A. J, Mifsud D. V, Kruuk L. E. B, J M Pemberton   +27 more
core   +1 more source

Non-random mating for selection with restricted rates of inbreeding and overlapping generations [PDF]

, 2002
Minimum coancestry mating with a maximum of one offspring per mating pair (MC1) is compared with random mating schemes for populations with overlapping generations. Optimum contribution selection is used, whereby ΔF is restricted.
Anna K Sonesson, Theo HE Meuwissen, Sonesson Anna K, Anna K. Sonesson, Meuwissen, Theo, Meuwissen, T.H.E., Sonesson, Anna, Theo H.E. Meuwissen, Meuwissen Theo HE, Sonesson, A.K.   +9 more
core   +1 more source

Long-Term Impact of Optimum Contribution Selection Strategies on Local Livestock Breeds with Historical Introgression Using the Example of German Angler Cattle

G3: Genes, Genomes, Genetics, 2017
The long-term performance of different selection strategies was evaluated via simulation using the example of a local cattle breed, German Angler cattle.
Yu Wang, Dierck Segelke, Reiner Emmerling, Jörn Bennewitz, Robin Wellmann   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Selection on milk production and conformation traits during the last two decades in Japan [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective The purpose of this study was to compare intended and actual yearly genetic gains for milk production and conformation traits and to investigate the simple selection criterion practiced among milk production and conformation traits during the ...
Kenji Togashi, Takefumi Osawa, Kazunori Adachi, Kazuhito Kurogi, Kota Tokunaka, Takanori Yasumori, Tsutomu Takahashi, Kimihiro Moribe   +7 more
doaj   +1 more source

Increasing cassava root yield: Additive-dominant genetic models for selection of parents and clones

Frontiers in Plant Science, 2022
Genomic selection has been promising in situations where phenotypic assessments are expensive, laborious, and/or inefficient. This work evaluated the efficiency of genomic prediction methods combined with genetic models in clone and parent selection with
Luciano Rogério Braatz de Andrade, Massaine Bandeira e Sousa, Marnin Wolfe, Jean-Luc Jannink, Jean-Luc Jannink, Marcos Deon Vilela de Resende, Marcos Deon Vilela de Resende, Marcos Deon Vilela de Resende, Camila Ferreira Azevedo, Eder Jorge de Oliveira   +9 more
doaj   +1 more source

The genetical theory of multilevel selection [PDF]

Journal of Evolutionary Biology, 2015
Abstract The theory of multilevel selection ( MLS ) is beset with conceptual difficulties. Although it is widely agreed that covariance between group trait and group fitness may arise in the natural world and drive a response to ‘group selection’, ambiguity exists over the ...
openaire   +4 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source