Results 71 to 80 of about 2,157,533 (280)

Population genetics: The signature of selection [PDF]

Current Biology, 2001
There is hope that the structure of molecular variation within populations can give evidence for recent adaptive evolution. New work on Drosophila genes that seem to have been subject to adaptive changes illustrates the difficulties in calculating the statistical significance of data trends that seem to show this.
openaire   +2 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Identifying Signatures of Selection in Genetic Time Series

, 2013
Both genetic drift and natural selection cause the frequencies of alleles in a population to vary over time. Discriminating between these two evolutionary forces, based on a time series of samples from a population, remains an outstanding problem with ...
Feder, Alison, Kryazhimskiy, Sergey, Plotkin, Joshua B.   +2 more
core   +1 more source

Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]

, 2009
Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
core   +3 more sources

Comparative evaluation of phenotypic, pedigree, and family-based selection in insect breeding using stochastic simulation

Animal
Selective breeding in insects has predominantly relied on phenotypic selection without considering relatedness. Selection on estimated breeding values could potentially increase genetic gain, but the challenge of pedigree tracking complicates this ...
L.S. Hansen, A.C. Bouwman, G. Sahana, M. Slagboom, H.M. Nielsen, E.D. Ellen   +5 more
doaj   +1 more source

The quantitative genetic basis of female and male body size and their implications on the evolution of body size dimorphism in the house cricket Acheta domesticus (Gryllidae)

Genetics and Molecular Biology, 2005
Few theoretical and experimental studies have analyzed the genetic basis of body size dimorphism. Since the evolutionary response to selection depends of the genetic variance in a population it is to be expected that traits under selection would have ...
Raúl Cueva del Castillo
doaj   +1 more source

Detecting selection with a genetic cross [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Natural selection is the force that underlies the spectacular adaptations of all organisms to their environments. However, not all traits are under selection; a key question is which traits have been shaped by selection, as opposed to the random drift of neutral traits.
openaire   +2 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source