Results 81 to 90 of about 2,135,140 (326)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Integrating Selection Mapping With Genetic Mapping and Functional Genomics
Frontiers in Genetics, 2018 Genomic scans for signatures of selection allow us to, in principle, detect variants and genes that underlie recent adaptations. By combining selection mapping with genetic mapping of traits known to be relevant to adaptation, we can simultaneously ...
Martin Johnsson, Martin Johnsson
doaj +1 more source
Down-Sampled Epsilon-Lexicase Selection for Real-World Symbolic Regression Problems [PDF]
arXiv, 2023 Epsilon-lexicase selection is a parent selection method in genetic programming that has been successfully applied to symbolic regression problems. Recently, the combination of random subsampling with lexicase selection significantly improved performance in other genetic programming domains such as program synthesis.
arxiv
Genetic similarity promotes evolution of cooperation under lethal intergroup competition [PDF]
, 2008 Altruism (helping others at a cost to oneself) may evolve via group selection if the cost of altruism to the individual is compensated for by growth differences among groups when (1) there is high genetic variation among members of different groups; (2 ...
John Orbell, Oleg Smirnov
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. [PDF]
, 2016 Despite decades of work, our understanding of the distribution of fitness effects of segregating genetic variants in natural populations remains largely incomplete. One form of selection that can maintain genetic variation is spatially varying selection,
Begun, David J +3 more
core +4 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Genetic optimization algorithms applied toward mission computability models [PDF]
arXiv, 2020 Genetic algorithms are modeled after the biological evolutionary processes that use natural selection to select the best species to survive. They are heuristics based and low cost to compute. Genetic algorithms use selection, crossover, and mutation to obtain a feasible solution to computational problems.
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Optimizing the selection of quantitative traits in plant breeding using simulation
Frontiers in Plant ScienceThis review summarizes findings from simulation studies on quantitative traits in plant breeding and translates these insights into practical schemes. As agricultural productivity faces growing challenges, plant breeding is central to addressing these ...
Rafael Augusto Vieira +2 more
doaj +1 more source