Results 71 to 80 of about 586,435 (341)

Ship Type Selection and Cost Optimization of Marine Container Ships Based on Genetic Algorithm

Applied Sciences
In the context of the deep-sea transportation supply chain, this paper addresses the complex decision-making problem of vessel allocation and carbon emission optimization for container shipping routes.
Ping Xiao, Haiyan Wang
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Tag SNP selection via a genetic algorithm

Journal of Biomedical Informatics, 2010
Single Nucleotide Polymorphisms (SNPs) provide valuable information on human evolutionary history and may lead us to identify genetic variants responsible for human complex diseases. Unfortunately, molecular haplotyping methods are costly, laborious, and time consuming; therefore, algorithms for constructing full haplotype patterns from small available
Mahdevar, Ghasem, Zahiri, Javad, Sadeghi, Mehdi, Nowzari-Dalini, Abbas, Ahrabian, Hayedeh   +4 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Underwater target classification with optimized feature selection based on Genetic Algorithms [PDF]

, 2020
Rigel Procópio Fernandes, José Jr.
openalex   +1 more source

Energy Efficient Clustering using Binary Coded Tournament selection based Genetic Algorithm [PDF]

, 2022
K Lavanya, J Thilagavthi, A Puviarasu, R Roopa, Sinthiya Muruganantham, M Thangamani   +5 more
openalex   +1 more source

Inbreeding management and optimization of genetic gain with phenotypic and genomic selection in oil palm (Elaeis guineensis)[W776] [PDF]

, 2020
Oil palm breeding relies on reciprocal recurrent selection between two heterotic groups complementary for bunch number and average bunch weight. Given the long generation interval and the limited selection intensity imposed by the progeny tests currently
Cros, David, Sanchez, Leopoldo, Tchounke, Billy   +2 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Optimization of Combat Resource Allocation Based on Restricted Tournament Selection Social Genetic Algorithm

International Journal of Computational Intelligence Systems
To tackle the challenge of combat resource allocation problem (CRAP), especially under resource constraints, the dilemma between the efficiency of combat resource utilization and the efficiency of problem-solving.
Shandong Yuan, Yun Ren, Han Zhou, Yongjing Cheng, Kai Yan   +4 more
doaj   +1 more source

Evolutionary sequential genetic search technique-based cancer classification using fuzzy rough nearest neighbour classifier

Healthcare Technology Letters, 2018
Cancer is one of the deadly diseases of human life. The patient may likely to survive if the disease is diagnosed in its early stages. In this Letter, the authors propose a genetic search fuzzy rough (GSFR) feature selection algorithm, which is ...
Loganathan Meenachi, Srinivasan Ramakrishnan   +1 more
doaj   +1 more source