Results 111 to 120 of about 191,946 (295)

Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle [PDF]

, 2014
BACKGROUND: Signatures of selection are regions in the genome that have been preferentially increased in frequency and fixed in a population because of their functional importance in specific processes.
Pérez O'Brien, Ana M, Utsunomiya, Yuri T, Sonstegard, Tad S, George E Liu, Da Silva, Marcos Vb, Liu, George E, Utsunomiya, Yuri T., Liu, George E., O'Brien, Ana M. Perez, Bickhart, Derek M., Gábor Mészáros, José Garcia, Garcia, José Fernando, Pérez O’Brien, Ana M., Utsunomiya, Yuri T. [UNESP], Ana M Pérez O’Brien, Da Silva, Marcos V. B., Derek M Bickhart, Garcia, José Fernando [UNESP], Yuri T Utsunomiya, Bickhart, Derek M, Van Tassell, Curtis P, Curtis P Van Tassell, Marcos VB Da Silva, Mészáros, Gábor, Van Tassell, Curtis P., Tad S Sonstegard, Sölkner, Johann, Johann Sölkner, Sonstegard, Tad S., Soelkner, Johann   +30 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genetic legacy and adaptive signatures: investigating the history, diversity, and selection signatures in Rendena cattle resilient to eighteenth century rinderpest epidemics [PDF]

Background: Rendena is a dual-purpose cattle breed, which is primarily found in the Italian Alps and the eastern areas of the Po valley, and recognized for its longevity, fertility, disease resistance and adaptability to steep Alpine pastures.
Partel E., Chero Osorio A. M., Barbato M., Achilli A., Pilla F., Hauffe H. C., Colli L., Komjanc M., Ajmone Marsan P., Mantovani R., Somenzi E., Franceschi N.   +11 more
core   +1 more source

Detecting signatures of balancing selection to identify targets of anti-parasite immunity. [PDF]

, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

Luzhong mutton sheep: inbreeding and selection signatures

Journal of Animal Science and Technology, 2020
Intense artificial selection has been imposed to Luzhong mutton sheep population in the past years. Improvements on growth and reproductive performance are two breeding goals in the present herd. Although some progresses were phenotypically observed possibly due to inbreeding induced by strong selection in terms of these traits, the genomic evaluation ...
Lin Tao, Xiaoyun He, Fengyan Wang, Yingjie Zhong, Linxiang Pan, Xiangyu Wang, Shangquan Gan, Ran Di, Mingxing Chu   +8 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Feature Selection and Binarization for On-Line Signature Recognition [PDF]

, 2009
The representation of a biometric trait through a set of parametric features is commonly employed in many biometric authentication systems. In order to avoid any loss of useful information, large sets of features have been defined for biometric characteristics such as signature, gait or face.
Emanuele Maiorana, Patrizio Campisi, Alessandro Neri 0001   +2 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling.

PLoS ONE, 2014
Identifying relevant signatures for clinical patient outcome is a fundamental task in high-throughput studies. Signatures, composed of features such as mRNAs, miRNAs, SNPs or other molecular variables, are often non-overlapping, even though they have ...
Sangkyun Lee, Jörg Rahnenführer, Michel Lang, Katleen De Preter, Pieter Mestdagh, Jan Koster, Rogier Versteeg, Raymond L Stallings, Luigi Varesio, Shahab Asgharzadeh, Johannes H Schulte, Kathrin Fielitz, Melanie Schwermer, Katharina Morik, Alexander Schramm   +14 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source