Results 111 to 120 of about 2,802,986 (296)
Optimal strategy selection method for moving target defense based on signaling game
Tongxin xuebao, 2019 To solve the problem of the optimal strategy selection for moving target defense,the defense strategy was defined formally,the defense principle from the perspective of attack surface shifting and exploration surface enlarging was taken into account.Then,
Lyu JIANG, Hengwei ZHANG, Jindong WANG
doaj +2 more sources
PLoS Pathogens, 2012 Targeting of permissive entry sites is crucial for bacterial infection. The targeting mechanisms are incompletely understood. We have analyzed target-site selection by S. Typhimurium. This enteropathogenic bacterium employs adhesins (e.g.
Benjamin Misselwitz +14 more
doaj +1 more source
Mars Lander/Rover vehicle development: An advanced space design project for USRA and NASA/OAST [PDF]
A design is proposed for a Mars Lander/Rover (MLR) for use in gathering needed environmental and surface information. The design focus will be upon a Mars Lander/Rover that will leave an orbit around Mars, reenter and soft land on the Martian surface ...
core +1 more source
MODELS AND INFORMATION SYSTEMS OF ECOLOGICAL AND ECONOMICAL RISKS WITH DECISION MAKING ON THE CLOSURE OF COAL MINES [PDF]
, 2018 Development of decision support system based on simulation results of underworking of surface and selection of rational way of ...
ALEKSIEIEV, Mykhailo +6 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
mAbsAntibody therapeutics are a rapidly growing class of biopharmaceuticals, but concerns regarding potential developability issues persist. While complementarity-determining region (CDR) loops are imperative for antigen specificity and mutations are ...
Vera A. Spanke +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv [PDF]
, 2004 This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display
Roberts, Anthony Simon
core +1 more source