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Selective Autophagy Receptors in Neuronal Health and Disease
Journal of Molecular Biology, 2020Neurons are electrically excitable, postmitotic cells that perform sensory, relaying, and motor functions. Because of their unique morphological and functional specialization, cells of this type are sensitive to the stress caused by accumulation of misfolded proteins or damaged organelles.
Conway, Owen +3 more
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Cargo receptors and adaptors for selective autophagy in plant cells
FEBS Letters, 2022Plant selective (macro)autophagy is a highly regulated process where eukaryotic cells spatiotemporally degrade some of their constituents that have become superfluous or harmful. The identification and characterization of the factors determining this selectivity make it possible to integrate selective (macro)autophagy into plant cell physiology and ...
Ai My Luong +3 more
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Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression [PDF]
Cancer Cell, 2014 In selective autophagy, receptors are central for cargo selection and delivery. However, it remains yet unclear whether and how multiple autophagy receptors might form complex and function concertedly to control autophagy. Optineurin (OPTN), implicated genetically in glaucoma and amyotrophic lateral sclerosis, was a recently identified autophagy ...
Shiyao Chen +2 more
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Selective autophagy receptor Joka2 co-localizes with cytoskeleton in plant cells [PDF]
Plant Signaling and Behavior, 2014 Autophagy, especially selective autophagy, is poorly characterized in plants compared with mammals and yeasts, where numerous factors required for the proper regulation of autophagy have been identified. The evidence for the importance of the cytoskeleton (both actin filaments and microtubules) in various aspects of autophagy comes mostly from work on ...
Agnieszka Sirko +1 more
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A selective autophagy receptor identified
Science, 2018Biochemistry Autophagosomes engulf and degrade cellular components in lysosomes. Degradation of ribosomes is called ribophagy and is an important source of nutrients. Using a recently reported method to isolate lysosomes, Wyant et al. profiled the dynamics of the lysosomal proteome under different nutrient conditions (see the Perspective by Nofal and ...
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Selective autophagy receptor hinders antitumor immunity
Trends in CancerAutophagy has a dual role in tumor progression and therapy, influenced by specific receptors and cargo selection. Recent research published in Cell by Herhaus et al. identifies immunity-related GTPase Q (IRGQ) as a novel autophagy receptor that facilitates immune evasion in hepatocellular carcinoma (HCC) by degrading histocompatibility complex class I (
Jiao Liu, Rui Kang, Daolin Tang
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Studies of Receptor-Atg8 Interactions During Selective Autophagy
2019Autophagy research frequently requires the determination of protein-protein interactions. The experimental system described in this chapter allows a simple, versatile, and quantitative in vitro analysis of interactions between recombinant cargo receptor and Atg8 proteins by fluorescence microscopy.
Abert, Christine, Martens, Sascha
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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
Nature, 2015Macroautophagy (hereafter referred to as autophagy) degrades various intracellular constituents to regulate a wide range of cellular functions, and is also closely linked to several human diseases. In selective autophagy, receptor proteins recognize degradation targets and direct their sequestration by double-membrane vesicles called autophagosomes ...
Keisuke, Mochida +6 more
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The multifaceted roles of selective autophagy receptors in viral infections
Journal of VirologyABSTRACT Selective autophagy is a protein clearance mechanism mediated by evolutionarily conserved selective autophagy receptors (SARs), which specifically degrades misfolded, misassembled, or metabolically regulated proteins. SARs help the host to suppress viral infections by degrading viral proteins.
Rui Luo +6 more
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Selective Autophagy Regulates Innate Immunity Through Cargo Receptor Network
2019Autophagy, an evolutionarily conserved cargo degradation process, is responsible to remove superfluous and unwanted cytoplasmic materials and maintain cellular homeostasis. Autophagy can be highly selective and target specific cargoes by utilizing multiple cargo receptors, which bind both ubiquitinated cargoes and autophagosomes.
Yaoxing, Wu, Jun, Cui
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