Results 61 to 70 of about 78,923 (333)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Catalytic Performance of Ru/polymer Catalyst in the Hydrogenation of Furfural to Furfuryl Alcohol

Chemical Engineering Transactions, 2020
Furfural (FF) is one of the main components of bio-oil obtained by the treatment of lignocellulose biomass. Furfural alcohol (FA) as the main product of the selective FF hydrogenation is a source of value-added chemicals.
Mikhail Sulman, Valentina Matveeva, Ksenia Salnikova, Yurii Larichev, Stepan Mikhailov, Alexey Bykov, Galina Demidenko, Alexander Sidorov, Esther Sulman   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Optimizing reaction paths for methanol synthesis from CO2 hydrogenation via metal-ligand cooperativity

Nature Communications, 2019
Controlling the reaction path is instrumental for developing efficient catalysts for CO2 hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve ...
Yizhen Chen, Hongliang Li, Wanghui Zhao, Wenbo Zhang, Jiawei Li, Wei Li, Xusheng Zheng, Wensheng Yan, Wenhua Zhang, Junfa Zhu, Rui Si, Jie Zeng   +11 more
doaj   +1 more source

Co2FeGe Heusler Alloy Nanoparticle Catalysts for Propyne Hydrogenation and Ammonia Decomposition

ChemistryOpen, 2023
Heusler alloys (X2YZ) can be a candidate for new catalysts as well as other intermetallic compounds. We previously found good catalytic properties of Co2FeGe for selective hydrogenation of alkynes and developed nanoparticles of Co2FeGe supported on SiO2.
Dr. Takayuki Kojima, Yuki Nakaya, Souta Tate, Prof. Dr. Satoshi Kameoka, Prof. Dr. Shinya Furukawa   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Elucidating the structure-activity relationship of the bimetallic Ni-Cu catalysts for CO2 hydrogenation

Journal of CO2 Utilization
The conversion of carbon dioxide (CO2) into high-value products plays a critical role in mitigating atmospheric CO2 levels. Recently, low-cost Ni-based catalysts have been garnering attention due to their exceptional hydrogenation ability.
Yifei Feng, Liang Shen, Wenhao Zhang, Xiaohan Yuan, Minghui Zhu, Jing Xu   +5 more
doaj   +1 more source

Supported Bimetallic AuPd Nanoparticles as a Catalyst for the Selective Hydrogenation of Nitroarenes

Nanomaterials, 2018
The solvent-free selective hydrogenation of nitrobenzene was carried out using a supported AuPd nanoparticles catalyst, prepared by the modified impregnation method (MIm), as efficient catalyst >99% yield of aniline (AN) was obtained after 15 h at 90 &
Ruiyang Qu, Margherita Macino, Sarwat Iqbal, Xiang Gao, Qian He, Graham John Hutchings, Meenakshisundaram Sankar   +6 more
doaj   +1 more source