Results 61 to 70 of about 65,032 (285)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Three-Dimensional Dynamic Supramolecular "Sticky Fingers" Organic Framework. [PDF]

, 2019
Engineering high-recognition host-guest materials is a burgeoning area in basic and applied research. The challenge of exploring novel porous materials with advanced functionalities prompted us to develop dynamic crystalline structures promoted by soft ...
Costa, José Sánchez, Fernandez-Bartolome, Estefania, Gamonal, Arturo, Khodabakhshi, Saeed, Martín, Nazario, McCormick, Laura J, Santos, José, Sañudo, E Carolina, Teat, Simon J   +8 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimizing reaction paths for methanol synthesis from CO2 hydrogenation via metal-ligand cooperativity

Nature Communications, 2019
Controlling the reaction path is instrumental for developing efficient catalysts for CO2 hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve ...
Yizhen Chen, Hongliang Li, Wanghui Zhao, Wenbo Zhang, Jiawei Li, Wei Li, Xusheng Zheng, Wensheng Yan, Wenhua Zhang, Junfa Zhu, Rui Si, Jie Zeng   +11 more
doaj   +1 more source

Co2FeGe Heusler Alloy Nanoparticle Catalysts for Propyne Hydrogenation and Ammonia Decomposition

ChemistryOpen, 2023
Heusler alloys (X2YZ) can be a candidate for new catalysts as well as other intermetallic compounds. We previously found good catalytic properties of Co2FeGe for selective hydrogenation of alkynes and developed nanoparticles of Co2FeGe supported on SiO2.
Dr. Takayuki Kojima, Yuki Nakaya, Souta Tate, Prof. Dr. Satoshi Kameoka, Prof. Dr. Shinya Furukawa   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

CO2 Hydrogenation to Formate and Formic Acid by Bimetallic Palladium-Copper Hydride Clusters. [PDF]

, 2020
Mass spectrometric analysis of the anionic products of interaction between bimetallic palladium-copper tetrahydride anions, PdCuH4-, and carbon dioxide, CO2, in a reaction cell shows an efficient generation of the PdCuCO2H4- intermediate and formate ...
Alexandrova, Anastassia N, Blankenhorn, Moritz, Bowen, Kit H, Liu, Gaoxiang, Marshall, Mary, Poths, Patricia, Zhang, Xinxing, Zhu, Zhaoguo   +7 more
core   +1 more source

Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials [PDF]

, 2019
Electrochemical hydrogenation has emerged as an environmentally benign and operationally simple alternative to traditional catalytic reduction of organic compounds.
Ge, Haibo, Li, Bijin
core   +1 more source