Results 181 to 190 of about 6,519,664 (285)

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Novel application of Yttrium-90 microsphere selective internal radiation therapy in hepatic metastases of primary fallopian tube carcinoma. [PDF]

Hepatobiliary Surg Nutr
Li X, Jiang Y, Mo Z, Feng X, Zhang L, Yu Z.   +5 more
europepmc   +1 more source

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

Yttrium-90 Selective Internal Radiation Therapy for Neuroendocrine Liver Metastases: An Institutional Case Series, Updated Systematic Review, and Meta-Analysis. [PDF]

Diagnostics (Basel)
Zheng X, Wen F, Xi H, Sluis JV, Bokkers RPH, Lütje S, Kater GM, Hoogwater FJH, Walenkamp AME, de Groot DA, Ruiter SJS, Noordzij W.   +11 more
europepmc   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Loss of both diffusion restriction and arterial enhancement can predict complete pathological response following Y-90 selective internal radiation therapy for hepatocellular carcinoma. [PDF]

Abdom Radiol (NY)
Lim KHA, Clifford MJ, Ormiston W, Khor TS, Ngo KQS, Rowcroft A, Mou L, Delriviere L, Wallace M, Bhandari M, Ballal M, Tibballs J.   +11 more
europepmc   +1 more source

Near‐Unity Photothermal Conversion in Bimetallic M44 and M81 Nanoclusters Enables NIR‐Driven Photo‐Thermo‐Electricity Generation

Advanced Science, EarlyView.
Atomically precise nanoclusters of Au/Ag alloys are explored as high‐performance photothermal materials, delivering record‐high photothermal efficiencies (up to 91%). Photo‐thermo‐electricity is further demonstrated by integrating nanocluster films with thermoelectric devices.
Avirup Sardar, Abhrojyoti Mazumder, Weijie Ji, Guiying He, Yitong Wang, Lianshun Luo, Sihan Chen, Rongchao Jin   +7 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source