Elucidating binding hot spots and structural stability in sirtuin family proteins for selective inhibitors: a computational approach [PDF]
Frontiers in BioinformaticsBackgroundThe sirtuin (SIRT) family is an NAD+-dependent class III histone deacetylase protein that comprises seven members (SIRT1–7). SIRTs are involved in many cellular pathways, which enable them to act as significant regulators of critical diseases ...
Deepak Sharma, Rajiniraja Muniyan
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Radiation safety aspects of 90Y bremsstrahlung radiation produced from radiation shielding apparatus using the Monte Carlo simulation [PDF]
Nuclear Technology and Radiation Protection, 2021 Selective internal radiation therapy using an 90Y labelled microsphere is increasingly used to treat hepatocellular carcinoma. Based on its properties, 90Y can produce bremsstrahlung radiation which is essential for post-treatment localisation ...
Jumpee Chayanit +4 more
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PREVALENCE OF INTESTINAL PARASITIC INFECTION AMONG PRIMARY SCHOOL CHILDREN IN SIRT-LIBYA [PDF]
Journal of Productivity and Development, 2013 This study was carried out to determine the prevalence of intestinal parasitic infection in primary school children in eight primary schools in Sirt city, Libya.
Hamed. Kassem +2 more
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Yttrium-90 transarterial radioembolization for liver metastases from medullary thyroid cancer
European Thyroid Journal, 2023 Objectives: Liver metastases occur in 45% of patients with advanced metastatic medullary thyroid cancer (MTC). Transarterial radioembolization (TARE) has been proposed to treat liver metastases (LM), especially in neuroendocrine tumors.
Luciana Puleo +15 more
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Advances in Radiation Oncology, 2021 Purpose: Selective internal radiation therapy (SIRT) is administered to treat tumors of the liver and is generally well tolerated. Although widely adopted for its therapeutic benefits, SIRT is rarely combined with external beam radiation therapy (EBRT ...
Elliot Abbott, DPhil, MSc +6 more
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Comparative Study of SIRT1 Expression in Hepatitis B Virus, Hepatitis C Virus, and Hepatocellular Carcinoma Patients [PDF]
Egyptian Journal of Medical Research, 2022 Background and Aim: The most common form of primary liver cancer in adults is hepatocellular carcinoma (HCC), and it is the most common cause of death in people with cirrhosis.
Ahmed Ibrahim +3 more
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SIRT-1 is required for release of enveloped enteroviruses
eLife, 2023 Enterovirus D68 (EV-D68) is a re-emerging enterovirus that causes acute respiratory illness in infants and has recently been linked to Acute Flaccid Myelitis.
Alagie Jassey +7 more
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Value of hysteroscopy in management of unexplained infertility
Asian Pacific Journal of Reproduction, 2014 Objective: To assess the value of hysteroscopy in unexplained infertility. Methods: 200 infertile women in whom standard infertility investigations revealed no abnormalities were included in the study between January 2009 and December 2013.
Aisha M. Elbareg +3 more
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The sirtuin family in health and disease
Signal Transduction and Targeted Therapy, 2022 Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes.
Qi-Jun Wu +15 more
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Sleep, Sirtuin 1 and Alzheimer’s disease: A review
Aging Brain, 2022 Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer’s disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded
Mehrane Mehramiz +3 more
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