Results 41 to 50 of about 22,785 (248)

Petroleum systems of the Sirt Basin, Libya

, 2017
\ua9 2017, Society of Petroleum Engineers. The petroleum systems of the Sirt Basin province were evaluated based on the burial history, thermal maturity and timing of the generation of oil and/or gas.
Jones M, Dieb M
core   +4 more sources

In vivo comparison of micro-balloon interventions (MBI) advantage: a retrospective cohort study of DEB-TACE versus b-TACE and of SIRT versus b-SIRT

, 2022
Purpose The purpose of this study was to evaluate in vivo the role of the micro-balloon by comparing trans-arterial chemoembolization (DEB-TACE) and selective internal radiotherapy (SIRT) procedures performed with and without balloon micro-catheter (b ...
De Gyurgyokai, Simone Zilahi, Trobiani, Claudio, Masi, Marica, Cappelli, Federico, Pecorella, Irene, Vallati, Giulio, Lucatelli, Pierleone, Ungania, Sara, Rocco, Bianca, Catalano, Carlo, Lai, Quirino, De Rubeis, Gianluca   +11 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Mongolian Patients with Advanced Hepatocellular Carcinoma: A Subgroup Analysis of the SIRveNIB Study

Central Asian Journal of Medical Sciences, 2019
Objective: The purpose of this study was to compare the efficacy and safety of selective internal radiation therapy and sorafenib on advanced hepatocellular carcinoma.
Ariunaa Khasbazar, Sanduijav Rubjir, Baasanjav Nachin, Baatarkhuu Oidov   +3 more
doaj   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Adrenocortical carcinoma: selective internal radiation therapy and liver metastases

Endocrine Oncology
Selective internal radiation therapy (SIRT) is a novel intervention for both primary and metastatic malignant liver lesions. Adrenocortical carcinoma (ACC) is rare with limited treatment options; evidence for SIRT in ACC liver metastases consists of case
Leo Baxendale-Smith, Karim El-Shakankery, James Gordon-Smith, Lucy Wall   +3 more
doaj   +1 more source

Sirtuins (SIRTs) As a Novel Target in Gastric Cancer

International Journal of Molecular Sciences, 2022
Gastric cancer is a major health burden worldwide. Among all neoplasms, gastric cancer is the fifth most common and the third most deadly type of cancer. It is known that sirtuins (SIRTs), are NAD+-dependent histone deacetylases regulating important metabolic pathways.
Agata Poniewierska-Baran, Paulina Warias, Katarzyna Zgutka   +2 more
openaire   +2 more sources

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section

Neuropsychiatric Disease and Treatment, 2020
Shi-Chao Luo,1 Kai-Ming Duan,1 Chao Fang,1,2 Dan-Yang Li,1 Shan-Shan Zheng,1 Si-Qi Yang,1 Shu-Ting Yang,1 Mi Yang,1 Liang-Bin Zhang,1 Sai-Ying Wang1 1Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013 ...
Luo SC, Duan KM, Fang C, Li DY, Zheng SS, Yang SQ, Yang ST, Yang M, Zhang LB, Wang SY   +9 more
doaj  

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source