Results 51 to 60 of about 22,785 (248)

Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats.

PLoS ONE, 2019
BackgroundAdiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molecule sharing common targets and cellular activities with SIRT-1.
Maria Assunta Potenza, Luca Sgarra, Carmela Nacci, Valentina Leo, Maria Antonietta De Salvia, Monica Montagnani   +5 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. [PDF]

PLoS ONE, 2012
OBJECTIVE: Osteogenic repair in response to bone injury is characterized by activation and differentiation of mesenchymal stem cells (MSCs) to osteoblasts. This study determined whether activation of Sirt-1 (a NAD(+)-dependent histone deacetylase) by the
Mehdi Shakibaei, Parviz Shayan, Franziska Busch, Constance Aldinger, Constanze Buhrmann, Cora Lueders, Ali Mobasheri   +6 more
doaj   +1 more source

Twenty Years of Radiation Therapy of Unresectable Intrahepatic Cholangiocarinoma: Internal or External? A Systematic Review and Meta-Analysis

Liver Cancer, 2021
Purpose: Both external beam radiation therapy (EBRT) and selective-internal radiation therapy (SIRT) are implemented to treat unresectable intrahepatic cholangiocarcinoma (iCCA).
Qian Yu, Chenyu Liu, Anjana Pillai, Osman Ahmed   +3 more
doaj   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Current density distribution for the quantum Hall effect

New Journal of Physics
Our microscopic understanding of the integer quantum Hall effect is still incomplete. For decades, there has been a controversial discussion about ‘where the current flows’ if the Hall resistance is quantized.
Serkan Sirt, Stefan Ludwig
doaj   +1 more source

The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential

Medicina
Background and Objectives: The aim of this study was to investigate the changes in the SIRT family, the effects of sirtuins on kidney graft function, and their potential as biomarkers in patients who develop rejection after kidney transplantation ...
Necip Altundaş, Eda Balkan, Murat Kizilkaya, Murat Altunok, Elif Demirci, Nurhak Aksungur, Salih Kara, Gürkan Öztürk, Abdullah Uyanik   +8 more
doaj   +1 more source

Role of SIRT-2 in the endotoxin tolerant RAW cells.

, 2016
A: RAW cells undergo endotoxin tolerance as early as 4h after LPS stimulation: To study endotoxin tolerance in RAW cells, we stimulated cells with LPS (100ng/ml) and re-stimulated with another LPS challenge (100ng/ml) at 0, 4, 6, 8, and 24 hour time ...
Xianfeng Wang (120153), Charles E. McCall (80208), Vidula Vachharajani (2921724), Barbara Yoza (2921727), Jonathan Wells (379115), Nancy L. Buechler (2921721), Ayana Martin (2921730)   +6 more
core   +1 more source

Dynamic prediction of coal and gas outburst risk based on quantitative analysis of stress–energy evolution and adaptive correction

Deep Underground Science and Engineering, EarlyView.
This study quantitatively analyzed the spatiotemporal evolution of stress redistribution ahead of the working face by integrating coal seam distribution, tectonic stress anomalies, gas pressure, and mining‐induced disturbances. An R‐value criterion for coal and gas outburst (CGO) risk assessment was established based on energy principles.
Yingjie Zhao, Xueqiu He, Dazhao Song, Liming Qiu, Minggong Guo, Jie Liu, Qiang Liu, Yi Zhu   +7 more
wiley   +1 more source

Analysis of Isotropic Beams Using Method of Initial Functions (MIF)

Electronic Journal of Structural Engineering, 2014
In this paper, method of initial functions (MIF) has been used to analyse the isotropic beams. The method of initial function is an analytical method of elasticity theory.
Rakesh Patel, S. K. Dubey, K. K. Pathak
doaj   +1 more source