Results 61 to 70 of about 22,785 (248)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy

BMC Cancer, 2020
Background Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable.
Ligia Craciun, Roland de Wind, Pieter Demetter, Valerio Lucidi, Ali Bohlok, Sébastien Michiels, Fikri Bouazza, Michael Vouche, Ilario Tancredi, Gontran Verset, Soizic Garaud, Céline Naveaux, Maria Gomez Galdon, Karen Willard Gallo, Alain Hendlisz, Ivan Duran Derijckere, Patrick Flamen, Denis Larsimont, Vincent Donckier   +18 more
doaj   +1 more source

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation

Signal Transduction and Targeted Therapy, 2022
Nicotinamide adenine dinucleotide (NAD+) is indispensable for the anti-aging activity of the sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD+ synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase ...
Hui Gong, Honghan Chen, Peng Xiao, Ning Huang, Xiaojuan Han, Jian Zhang, Yu Yang, Tiepeng Li, Tingting Zhao, Haoran Tai, Weitong Xu, Gongchang Zhang, Chuhui Gong, Ming Yang, Xiaoqiang Tang, Hengyi Xiao   +15 more
doaj   +1 more source

Monitoring of total and regional liver function after SIRT [PDF]

, 2014
Selective internal radiation therapy (SIRT) is a promising treatment modality for advanced hepatocellular carcinoma or metastatic liver cancer. SIRT is usually well tolerated.
Peter L Jansen, Peter L. Jansen, Bennink, Roelof J., Cieslak, Kasia P., Otto M. van Delden, Jansen, Peter L., van Delden, Otto M., Otto M van Delden, Thomas M. van Gulik, van Gulik, Thomas M., Krijn P van Lienden, Krijn P. van Lienden, Roelof J Bennink, Thomas M van Gulik, Klümpen, Heinz-Josef, Roelof J. Bennink, Kasia P. Cieslak, van Lienden, Krijn P., Heinz-Josef eKlümpen, Kasia P Cieslak, Heinz-Josef Klümpen   +20 more
core   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

SIRT Innovation (Booth)

, 2023
Visit the Screen Industries Research and Training Centre (SIRT) booth to witness, experience and learn about their expertise in the screening and media industries.
Screen Industries Research and Training Centre,
core  

Lebergerichtete Tumortherapie: Stellenwert der SIRT bei mNET und Cholangiokarzinom

, 2012
Bei Lebermetastasen neuroendokriner Tumoren (mNET) gewinnt die SIRT (selektive interne Radiotherapie) unter den lebergerichteten Therapien zunehmend an Bedeutung.
Angelika Bischof
core   +1 more source

Dominant negative SirT-1 (H363Y) and HDACIs enhanced hyperthermia-induced cell death.

, 2014
A. SirT-1 is involved in the cytoprotection from hyperthermia. Western blot shows the over-expressed SirT-1. FACS analysis of H1299 cells after transient transfection either with wide type SirT-1, dominant negative SirT-1 or FLAG expression vector. H363Y/
Zainab Mohamed (550766), Ahmed S. Sultan (550765), Yusuke Ohba (232743), Mohamed K. Hassan (550762), Hidemichi Watari (550763), Alaa-eldin Salah-eldin (550764), Yoichiro Fujioka (232732), Noriaki Sakuragi (550767)   +7 more
core   +1 more source

A Numerical Study on Travel Time Based Hydraulic Tomography Using the SIRT Algorithm with Cimmino Iteration [PDF]

, 2019
Travel time based hydraulic tomography is a technique for reconstructing the spatial distribution of aquifer hydraulic properties (e.g., hydraulic diffusivity). Simultaneous Iterative Reconstruction Technique (SIRT) is a widely used algorithm for travel
Yang, Huichen, Junjie Qi, Qiu, Pengxiang, Thomas Ptak, Hu, Rui, Rui Hu, Linwei Hu, Pengxiang Qiu, Yixuan Xing, Huichen Yang, Ptak, Thomas, Quan Liu, Xing, Yixuan, Liu, Quan, Qi, Junjie, Hu, Linwei   +15 more
core   +1 more source

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto, Martha Gulati, Suvarna S. Khadilkar, Angela H. E. M. Maas, Federica Frezet, Gláucia Maria Moraes de Oliveira, Andrea R. Genazzani, Hema Divakar, Athena Poppas, on behalf of the World Heart Federation (WHF) and the International Federation of Gynecology and Obstetrics (FIGO)   +9 more
wiley   +1 more source