Results 81 to 90 of about 22,785 (248)

SIRT TARANGLIK KUCHI

Ushbu maqolada sirt taranglik kuchining fizik mohiyati, uning kelib chiqish sabablari va suyuqliklarning xossalariga ta’siri yoritilgan. Sirt taranglik hodisasi molekulalararo o‘zaro ta’sir natijasida yuzaga kelib, suyuqlik sirtining elastik pardaga o‘xshash xususiyat kasb etishiga olib keladi.
Mamatova, Go'zaloy Jo'ramirzayevna, Abidova, Gulnozaxon Roʻzioxun qizi   +1 more
openaire   +3 more sources

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

, 2010
Sirtuins, commonly referred to as SIRTs, are a family of seven mammalian NAD+-dependent deacetylases implicated in the regulation of critical biological processes, including metabolism, cell division, differentiation, survival, and senescence.
Olmos Buchelt, Yolanda, Brosens, Jan J., Olmos, Yolanda, Yolanda Olmos, Lam, Eric W.-F., Eric W.-F. Lam, Jan J. Brosens   +6 more
core   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Protective Effect of Epigallocatechin‐3‐Gallate Against Fructose‐Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) lacks effective pharmacological therapies and is strongly associated with excessive fructose consumption. Ferroptosis and autophagy dysregulation are increasingly recognized as key drivers of MAFLD progression.
Puyu Zhang, Cuiping Hou, Jiayi Liu, Bosheng Wang, Wenqi Liu, Xin Yang, Yubing Kang, Zequn Liu, Yalin Zhang, Zhuxi Liu, Yuhong Zhao, Lu Zhao   +11 more
wiley   +1 more source

TIBBIYOTDA SIRT TARANGLIK KOEFFITSENTINI ANIQLASHNING AHAMIYATI

Ushbu maqolada sirt taranglik koeffitsenti va uning tibbiyotdagi ahamiyati bo’yicha ma’lumotlar keltirilgan. Tibbiyot amaliyotida sirt taranglik koeffitsentini aniqlash usullari va amaliy natijalari bo’yicha tahlillar ...
Aktamkulova, F.S., Qayumova, M.K., Xursandboyeva, G.F., Xodjayeva, D.Z.   +3 more
core   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Study

Advances in Radiation Oncology
Purpose: Selective internal radiation therapy (SIRT) can result in heterogeneous absorbed dose coverage. To address potential underdosing of lesions with SIRT, we designed a phase 1 clinical trial (NCT04518748) to add stereotactic body radiation therapy (
Daniel F. Polan, PhD, Justin K. Mikell, PhD, Kellen Fitzpatrick, MS, Joseph J. Gemmete, MD, Jared A. Christensen, MD, Hassan Anbari, MD, Molly Roseland, MD, Joseph R. Evans, MD, PhD, Daniel T. Chang, MD, Mamadou Sanogo, MD, Baljendra S. Kapoor, MD, Matthew J. Schipper, PhD, Yue Cao, PhD, Madhava P. Aryal, Theodore S. Lawrence, MD, PhD, Kyle C. Cuneo, MD, Yuni K. Dewaraja, PhD   +16 more
doaj   +1 more source

Telomeres get SIRT-ified [PDF]

Journal of Cell Biology, 2010
![Figure][1] A cell lacking SIRT1 (right) shows increased DNA damage (green) at chromosome ends (red). A protein that protects against aging-related diseases maintains telomere length and integrity, [Palacios et al.][2] reveal. Telomeres protect chromosome ends but grow shorter with age,
openaire   +1 more source

Energy‐Resolved Localized Surface Plasmon Resonances With Non‐Monochromated STEM‐EELS Assisted by Multivariate Analysis

Small Methods, EarlyView.
Transmission Electron Microscopy is a powerful technique, able to provide morphological, chemical, and optical/electronic information, yet some of these features require the use of highly expensive machines such as monochromated microscopes. In this work, we used low dose, low voltage, and mathematical treatment to gain energy resolution in an ...
Sara D. Catingan, Wanting He, Carlos F. Destefani, Jesus Valdez, Lucas V. Besteiro, Audrey Moores   +5 more
wiley   +1 more source