Results 71 to 80 of about 22,785 (248)

SIRT-2 inhibition during hypo-inflammatory phase activates circulating leukocytes.

, 2016
We treated ob/ob mice with either Vehicle of AK-7 during hypo-inflammatory phase of sepsis and studied whole blood leukocytes for PSGL-1 and CD45 expression using flow cytometry.
Xianfeng Wang (120153), Charles E. McCall (80208), Vidula Vachharajani (2921724), Barbara Yoza (2921727), Jonathan Wells (379115), Nancy L. Buechler (2921721), Ayana Martin (2921730)   +6 more
core   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Selective Internal Radiation Therapy for Gastrointestinal Neuroendocrine Tumour Liver Metastases: A New and Effective Modality for Treatment

International Journal of Hepatology, 2011
Background. Nonresectable neuroendocrine tumour (NET) liver metastases respond poorly to most widely available and used therapies. Selective Internal Radiation Therapy (SIRT) is becoming recognized as a new modality for selectively treating non ...
Harshal Rajekar, Kashan Bogammana, Richard S. Stubbs   +2 more
doaj   +1 more source

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM

Cells, 2018
Background and Purpose: Mitochondrial dysfunction remains the crucial cause for many heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein deacetylase localized in the mitochondria and regulates mitochondrial function ...
Pankaj K. Bagul, Parmeshwar B. Katare, Paramesha Bugga, Amit K. Dinda, Sanjay K. Banerjee   +4 more
doaj   +1 more source

Ratio in SIRT.

, 2012
The asynchronous I/O is the best of the three schemes, but in SIRT there is not a significant difference between using one or two hard disks. It can also be observed that buffers as big as in WBP are not needed to obtain good ratios.
José Jesús Fernández (124330), Jose-Ignacio Agulleiro (124327)   +1 more
core   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Prognostic factors influencing outcomes in hepatocellular carcinoma patients undergoing selective internal radiation therapy

Annals of Hepatology
Selective internal radiation therapy (SIRT) has emerged as a viable endovascular treatment strategy for hepatocellular carcinoma (HCC). According to the Barcelona Clinic Liver Cancer (BCLC) classification, SIRT is currently recommended for early- and ...
Maria Stella Franzè, Paul Vigneron, Anna Sessa, Carlo Saitta, Julia Chalaye, Vania Tacher, Alain Luciani, Hélène Regnault, Ancuta Bejan, Rami Rhaiem, Daniele Sommacale, Vincent Leroy, Raffaele Brustia, Giovanni Raimondo, Giuliana Amaddeo   +14 more
doaj   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Oxidative stress and regulation of adipogenic differentiation capacity by sirtuins in adipose stem cells derived from female patients of advancing age

Scientific Reports
Patient age is critical for mesenchymal stem cell quality and differentiation capacity. We demonstrate that proliferation and adipogenic capacity of subcutaneous adipose stem cells (ASCs) from female patients declined with advanced age, associated with ...
Anne Bernhardt, Alan Jamil, Md. Tanvir Morshed, Pia Ponnath, Veronika Gille, Nadine Stephan, Heinrich Sauer, Maria Wartenberg   +7 more
doaj   +1 more source