Results 221 to 230 of about 89,275 (314)

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö   +8 more
wiley   +1 more source

Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres. [PDF]

open access: yesCommun Biol
Shen Y   +9 more
europepmc   +1 more source

Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 545-555, February 2026.
Aims Globally, Australia has the highest per capita consumption rate of pregabalin, commonly prescribed for neuropathic pain. Emerging evidence suggests pregabalin may be associated with the onset or recurrence of several potentially life‐threatening psychiatric events in some individuals.
Amy G. McNeilage   +4 more
wiley   +1 more source

From Struggling (With) Screening Tests to Mouse Models of Depression‐Relevant Neurobehavioral States

open access: yesCurrent Protocols, Volume 6, Issue 2, February 2026.
Abstract A major, serendipitous psychiatric discovery is monoamine‐transporter reuptake inhibition as an antidepressant mechanism of action. Chronic treatment with such antidepressants is efficacious, with onset requiring 1‐2 weeks, in many but by no means all patients with major depressive or another stress‐related neuropsychiatric disorder.
Christopher R. Pryce
wiley   +1 more source

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