Ibrain, EarlyView., 2023 This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju +7 more
wiley +1 more source
Efficacy and Safety of Antidepressants for the Treatment of Irritable Bowel Syndrome: A Meta-Analysis. [PDF]
PLoS ONE, 2015 The aim of this meta-analysis was to analyze the efficacy and safety of antidepressants for the treatment of irritable bowel syndrome.We searched MEDLINE, EMBASE, Scopus and The Cochrane Library for randomized controlled trials investigating the efficacy
Chen Xie +6 more
doaj +1 more source
Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
core +4 more sources
Selective serotonin reuptake inhibitors and Alzheimer’s disease
Neural Regeneration Research, 2020 Given the failure to develop disease-modifying therapies for Alzheimer’s disease (AD), strategies aiming at preventing or delaying the onset of the disease are being prioritized. While the debate regarding whether depression is an etiological risk factor
Bernadette Mdawar +2 more
doaj +1 more source
Serotonin Reuptake Inhibitor Increases Pseudarthrosis Rates in Anterior Cervical Discectomy and Fusions [PDF]
Asian Spine Journal, 2023 Study Design Retrospective cohort. Purpose To determine (1) the effects of serotonin reuptake inhibitors in pseudarthrosis rates after anterior cervical decompression and fusion (ACDF) and (2) to identify patient-reported outcome measures in patients ...
Mark James Lambrechts +15 more
doaj +1 more source
Risk of suicide during treatment with venlafaxine, italopram, fluoxetine, and dothiepin : retrospective cohort study [PDF]
, 2006 Objective To compare the risk of suicide in adults usingthe antidepressant venlafaxine compared with citalopram, fluoxetine, and dothiepin. Design Retrospective cohort study. Setting UK General Practice Research Database. Participants 219 088 patients,
Andrews, Elizabeth +5 more
core +2 more sources
Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]
, 2011 Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg +14 more
core +1 more source
Chirality of Modern Antidepressants: An Overview [PDF]
Advanced Pharmaceutical Bulletin, 2017 The majority of modern antidepressants (selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors) have one or two centers of asymmetry in their structure; resulting in the formation of enantiomers which may ...
Monica Budău +4 more
doaj +1 more source
Neuropharmacological classification of antidepressant agents based on their mechanisms of action
Archives of Medicine and Health Sciences, 2018 The currently available clinical antidepressants can be classified into 13 different classes based on their mechanisms of action. These basic pharmacological concepts thoroughly elucidate and unravel the therapeutic actions and side effects of the wide ...
Olumuyiwa John Fasipe
doaj +1 more source
The effects of antidepressants appear to be rapid and at environmentally relevant concentrations [PDF]
, 2015 The effects of antidepressants on wildlife are currently raising some concern because of an increased number of publications indicating biological effects at environmentally relevant concentrations (\u3c100 ng/L).
Fong, Peter P., Ford, Alex
core +2 more sources