Results 81 to 90 of about 1,228,536 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen
A series of novel benzimidazole analogs is designed, synthesized, and screened against a panel of selected cancer cell lines, including H103 (oral squamous cell carcinoma, OSCC), H314 (OSCC), and HCT116 (colorectal carcinoma). Structural characterization
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Advances in the understanding of selective CO2 reduction catalysis

EcoEnergy
The electrochemical synthesis for value‐added chemicals and fuels via carbon dioxide reduction reaction (CO2RR) offers an effective route to close the anthropogenic carbon cycle and store renewable energy.
Ruihu Lu, Yan Liu, Ziyun Wang
doaj   +1 more source

Sponge-like Modified White-Rot Fungi Adsorbent for Rapid Removal of Pb(II) and Cd(II) from Solution: Selective Performance and Mechanistic Insights

Separations
Heavy metal pollution, especially from Pb(II) and Cd(II), poses significant risks due to its persistence and bioaccumulation potential. Traditional removal methods face challenges like high costs and secondary pollution.
Chunxiao Wang, Zhirong Chen, Nana Wang, Jianqiao Wang, Runshen He, Yu Chen, Haerfosai Nuhu, Hang Chen, Zhixuan Lin, Minqi Fan, Mingdong Chang   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exploring the Influence of Applied Potential and Catalyst Morphology on the Selectivities of Copper Toward Carbon Dioxide Electroreduction Using Machine Learning

Advanced Intelligent Systems
Electrochemical CO2 reduction (CO2RR) presents a sustainable approach to converting greenhouse gases into valuable chemicals. However, achieving precise product selectivity remains challenging.
Chengxi Yao, Mo Yan, Muhammad Asif, Ziyang Wang, Seungjae Lee, Joohwan Ha, Taesung Kim   +6 more
doaj   +1 more source

Towards Enhanced Gas Sensor Performance with Fluoropolymer Membranes

Sensors, 2016
In this paper we report on how to increase the selectivity of gas sensors by using fluoropolymer membranes. The mass transport of polar and non-polar gases through a polymer membrane matrix was studied by systematic selection of polymers with different ...
Thorsten Graunke, Katrin Schmitt, Stefan Raible, Jürgen Wöllenstein   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Glyphosate e associações em pós-emergência no desempenho agronômico e na qualidade das sementes de soja RR® Effect of glyphosate and associations in post-emergence on the agronomic performance and quality of RR® soybean seeds

Planta Daninha, 2012
O presente trabalho objetivou avaliar os componentes de produção e a qualidade das sementes de soja RR® em função da aplicação, em pós-emergência, de glyphosate isolado e em mistura em tanque.
L.P. Albrecht, D.G. Alonso, A.J.P. Albrecht, R.S. Oliveira JR., A.L. Braccini, J Constantin   +5 more
doaj   +1 more source