Results 121 to 130 of about 27,808 (261)

Eukaryotic selenoproteins and selenoproteomes

Biochimica et Biophysica Acta (BBA) - General Subjects, 2009
Selenium is an essential trace element for which both beneficial and toxic effects in human health have been described. It is now clear that the importance of having adequate amounts of this micronutrient in the diet is primarily due to the fact that selenium is required for biosynthesis of selenocysteine, the twenty first naturally occurring amino ...
Lobanov, Alexey V., Hatfield, Dolph L., Gladyshev, Vadim N.   +2 more
openaire   +3 more sources

Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation*

Journal of Biological Chemistry, 2017
Selenoproteins contain the amino acid selenocysteine (Sec), co-translationally inserted at a predefined UGA opal codon by means of Sec-specific translation machineries.
Q. Cheng, Elias S. J. Arnér
semanticscholar   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, Volume 36, Issue 30, 13 April 2026.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Bio-efficacy of hydroxy-selenomethionine as a selenium supplement in pregnant dairy heifers and on the selenium status of their calves [PDF]

, 2019
This study aimed to determine the effects of supplementing pregnant heifers with the organic selenium source 2-hydroxy-4-methylselenobutanoic acid (HMSeBA) during last eight weeks of pregnancy on dam and calf Se status. A total of 42 in-calf heifers were
Anderson, Apperson, Briens, Briens, Burk, Burk, C. Rymer, Calamari, Colakoglu, Cortinhas, D.T. Juniper, Gong, Gunter, Guyot, Hill, Howard, Jlali, Jlali, Juniper, Juniper, Juniper, Kincaid, Labunskyy, M. Briens, Martín-Venegas, McDonald, Meyer, Pehrson, Peters, Phipps, Rowntree, Salman, Seyedali, Slavik, Sneddon, Stockdale, Stowe, Sun, Sun, Sunde, Surai, Surai, Surai, Swecker, Touat-Hamici, Underwood, Vacchina, Vacchina, Wolffram   +48 more
core   +1 more source

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability

Nature Chemical Biology, 2022
Zhipeng Li, Lucas Ferguson, Kirandeep K. Deol, Melissa A. Roberts, Leslie Magtanong, Joseph M. Hendricks, G. Mousa, S. Kilinc, K. Schaefer, James A. Wells, M. Bassik, Andrei Goga, S. Dixon, Nicholas T. Ingolia, James A. Olzmann   +14 more
semanticscholar   +1 more source

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains

Nature Biotechnology, 2018
Incorporation of the rare amino acid selenocysteine to form diselenide bonds can improve stability and function of synthetic peptide therapeutics.
Ross Thyer, Raghav Shroff, Dustin R. Klein, Simon d’Oelsnitz, Victoria C Cotham, M. Byrom, J. Brodbelt, A. Ellington   +7 more
semanticscholar   +1 more source

Iron deficiency in heart failure: Epidemiology, diagnostic criteria and treatment modalities

ESC Heart Failure, Volume 12, Issue 2, Page 723-726, April 2025.
Stephan von Haehling
wiley   +1 more source

Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm [PDF]

, 2008
Dysregulation of calcium signals because of defects of the skeletal muscle sarcoplasmic reticulum calcium release channel (ryanodine receptor; RyR1) is causative of several congenital muscle disorders including malignant hyperthermia (MH; MIM #145600 ...
Jungbluth, Heinz, Muntoni, Francesco, Treves, Susan, Zorzato, Francesco   +3 more
core   +1 more source

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake [PDF]

, 2016
© The Royal Society of Chemistry 2015. Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia.
Busse, AL, Cardoso, BR, Cominetti, C, Cozzolino, SMF, Hare, DJ, Horst, MA, Jacob-Filho, W, Magaldi, RM, McColl, G   +8 more
core   +1 more source

A new allelic variant of rigid spine syndrome

Анналы клинической и экспериментальной неврологии, 2017
Description of clinical features of the disease in a 4-year-old boywith rigid spine syndrome is presented. Molecular genetic analysisrevealed in this patient an unknown homozygous mutation988delC in the SEPN1 gene (coding for selenoprotein N). Incontrast
E. L. Dadali, V. A. Kadnikova, I. V. Sharkova, A. V. Polyakov   +3 more
doaj   +1 more source