Results 131 to 140 of about 27,808 (261)

Thioredoxin reductase as a target enzyme for electrophilic anticancer drugs [PDF]

, 2011
Induced production of reactive oxygen species (ROS) is a common attribute of most cancer cells. One strategy for cancer cells to maneuver the increased and potentially toxic levels of ROS is to induce the expression of cellular antioxidants and ...
Eriksson, Sofi
core   +1 more source

The Association of Plasma Selenium and Selenoprotein P Levels with Depression Severity and Anxiety Symptoms Among Medical Students in Latvia

Medicina
Background and Objectives: Oxidative stress has been identified as a key process involved in different diseases, particularly depression. Selenium (Se) protects against oxidative stress, one of the pathogenic mechanisms involved in affective disorders ...
Zanda Birģele, Paula Marija Vimba, Anastasija Ševčenko, Andrejs Šķesters, Gunta Ancāne, Laura Valaine   +5 more
doaj   +1 more source

Pancreatic atrophy caused by dietary selenium deficiency induces hypoinsulinemic hyperglycemia via global down-regulation of selenoprotein encoding genes in broilers

PLoS ONE, 2017
This study was envisaged to comprehensively profile genes in selected tissues along with a few biochemical indicators and integrate resulting information with dietary selenium (Se) deficiency symptoms in broilers.
Jingyang Xu, Longqiong Wang, Jiayong Tang, G. Jia, Guangmang Liu, Xiaoling Chen, Jingyi Cai, Haiying Shang, Hua Zhao   +8 more
semanticscholar   +1 more source

Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster [PDF]

, 2003
Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the ...
Morey, Marta, Serras, Florenci, Corominas, Montserrat   +2 more
core   +1 more source

Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

Redox Biology, 2018
The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable.
Klaus Mayer, O. Mundigl, H. Kettenberger, Fabian Birzele, S. Stahl, I. Pastan, U. Brinkmann   +6 more
semanticscholar   +1 more source

Selenoproteins and selenoproteomes

, 2007
Recent progress in high-throughput sequencing and analysis allowed efficient identification of selenocysteine-containing proteins in sequence databases, including full sets of selenoproteins in organisms, designated selenoproteomes. Information is currently available on selenoproteomes from all major model organisms as well as humans, which have 25 ...
openaire   +2 more sources

Molecular mechanism of selenoprotein P synthesis.

Biochimica et Biophysica Acta - General Subjects, 2018
BACKGROUND Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors.
Sumangala P. Shetty, P. Copeland
semanticscholar   +1 more source

Selenoproteins and Thyroid Cancer

, 2011
Selenoproteins, in which Se exists in the form of selenocysteine, are essential for protection against oxidative damage and cancer. Genetic data has provided evidence that reduced levels of these proteins, induced by loss of heterozygosity or chromosomal alterations [1], result in cellular oxidative stress as well as derangement of signaling cascades ...
Duntas, L.H., Smyth, P.P.A.
openaire   +2 more sources

Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease

Antioxidants and Redox Signaling, 2016
Aims: Oxidative stress is central to the pathogenesis of Parkinson's disease (PD), but the mechanisms involved in the control of this stress in dopaminergic cells are not fully understood.
Loubna Boukhzar, Abdallah Hamieh, D. Cartier, Y. Tanguy, Ifat Alsharif, Matthieu T. Castex, A. Arabo, Sana El Hajji, J. Bonnet, M. Errami, A. Falluel-Morel, A. Chagraoui, I. Lihrmann, Y. Anouar   +13 more
semanticscholar   +1 more source

Selenium Utilization Strategy by Microalgae

Molecules, 2009
The diversity of selenoproteins raises the question of why so many life forms require selenium. Selenoproteins are found in bacteria, archaea, and many eukaryotes. In photosynthetic microorganisms, the essential requirement for selenium has been reported
Hiroya Araie, Yoshihiro Shiraiwa
doaj   +1 more source