Iron deficiency in heart failure: Epidemiology, diagnostic criteria and treatment modalities
ESC Heart Failure, Volume 12, Issue 2, Page 723-726, April 2025.
Stephan von Haehling
wiley +1 more source
GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer
Advanced Science, Volume 13, Issue 23, 23 April 2026.This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier +16 more
wiley +1 more source
Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake [PDF]
, 2016 © The Royal Society of Chemistry 2015. Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia.
Busse, AL +8 more
core +1 more source
Ferroptotic neurodegeneration and diet: a narrative review
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
Ximaine R. van der Burg +4 more
wiley +1 more source
Selenoprotein P. Its Structure and Functions.
Journal of Health Science, 2000 Selenoprotein P (SeP : the "P" denotes its presence in plasma) is the major selenoprotein in plasma. All selenoproteins so far reported contain one atom of selenium (Se) as selenocysteine per molecule except SeP, which is thought to contain ten atoms of Se as selenocysteine per molecule. SeP contains 50% of the total Se in plasma.
Yoshiro Saito, Kazuhiko Takahashi
openaire +2 more sources
Thioredoxin reductase as a target enzyme for electrophilic anticancer drugs [PDF]
, 2011 Induced production of reactive oxygen species (ROS) is a common attribute of most cancer cells. One strategy for cancer cells to maneuver the increased and potentially toxic levels of ROS is to induce the expression of cellular antioxidants and ...
Eriksson, Sofi
core +1 more source
Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster [PDF]
, 2003 Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the ...
Morey, Marta +2 more
core +1 more source
مجله دانشگاه علوم پزشکی بیرجند, 2023 Background and Aims: Non-alcoholic fatty liver disease is the accumulation of triglycerides in the liver. Modifying lifestyle, especially exercise and nutrition, are ways to control this disease.
Zohre Hosseini, Sadegh Cheragh-Birjandi
doaj
Selenoprotein P inhibits cell proliferation and ROX production in HCC cells.
PLoS ONE, 2020 Selenoprotein P (SEPP1) is a kind of secretory glycoproteins with an antioxidant effect during the development of some diseases. In this study, we attempted to observe the expression of SEPP1 in livers from the patients with hepatocellular carcinoma (HCC)
Jianxin Wang +8 more
doaj +1 more source
Low plasma selenium concentrations in critically ill children: the interaction effect between inflammation and selenium deficiency [PDF]
, 2014 Introduction: Low plasma selenium concentrations are frequent in critically ill patients. However, whether this is due to systemic inflammation, a deficient nutritional state or both is still not clear.
Iglesias, Simone Brasil de Oliveira +4 more
core +1 more source