Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
core +1 more source
Ccdc152 is not necessary for male fertility, but contributes to maintaining sperm morphology
The Journal of Reproduction and DevelopmentSelenoprotein P (SeP) is synthesized in the liver and plays a vital role in maintaining selenium homeostasis via transport throughout the body. Previous studies have shown that SeP-deficient mice have severely reduced expression of selenoproteins ...
Ryua HARIMA +8 more
doaj +1 more source
BMC Medical Genetics, 2017 Background Selenium is an essential trace and there is a high selenium concentration in the thyroid gland. Selenium deficiency may impair the thyroid function.
Ling Xiao +8 more
doaj +1 more source
Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
PLoS ONE, 2012 Selenium (Se) is an essential trace element for selenoprotein biosynthesis. Selenoproteins have been implicated in cancer risk and tumor development. Selenoprotein P (SePP) serves as the major Se transport protein in blood and as reliable biomarker of Se
Hellmuth A Meyer +7 more
doaj +1 more source
Determinants of selenium status in healthy adults
Nutrition Journal, 2011 Background Selenium (Se) status in non-deficient subjects is typically assessed by the Se contents of plasma/serum. That pool comprises two functional, specific selenoprotein components and at least one non-functional, non-specific components which ...
Hoeg Antonia +11 more
doaj +1 more source
Selenoprotein M is expressed during bone development [PDF]
, 2013 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational ...
Bösl, Michael +4 more
core
Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2. [PDF]
Commun Biol, 2023 Ye X +7 more
europepmc +1 more source
Role of CdTe quantum dots on peripheral Immunocytes and selenoprotein P: immunotoxicity at the molecular and cellular levels. [PDF]
Toxicol Res (Camb), 2023 Ma N +5 more
europepmc +1 more source
An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase. [PDF]
J Biol Chem, 2023 Mizuno A +14 more
europepmc +1 more source