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Self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?
Nature Reviews Drug Discovery, 2012Flemming Alexandra
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Protein therapy with self-amplifying RNA
ScienceSelf-amplifying RNA improves heart function after myocardial infarction in mice and ...
Lien Ervijn, Niek N. Sanders
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Self-amplifying RNA virus vectors for drug delivery
Expert Opinion on Drug DeliveryViral vectors have proven useful for delivering genetic information, such as drugs and vaccines, for therapeutic and prophylactic interventions. Self-amplifying RNA viruses possess the special feature of high-level RNA amplification in the host cell cytoplasm providing high antigen production against infectious pathogens and various types of cancers ...
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The recent COVID-19 pandemic as well as other past and recent outbreaks of newly or re-emerging viruses show the urgent need to develop potent new vaccine approaches, that enable a quick response to prevent global spread of infectious diseases. The breakthrough of first messenger RNA (mRNA)-based vaccines 2019 approved only months after identification ...
Louisa, Zimmermann, Stephanie, Erbar
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Louisa, Zimmermann, Stephanie, Erbar
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