Results 261 to 269 of about 57,349 (269)

Development of a self-amplifying RNA vaccine against Rift Valley fever

Background: Rift Valley fever (RVF) is a mosquito-borne zoonosis caused by the Rift Valley fever virus (RVFV), which leads to high mortality in livestock and severe or fatal complications in humans. Despite its severity, no licensed RVF vaccine exists for humans, and licensed livestock vaccines have suboptimal safety and immunogenicity.
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Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

Molecular Therapy, 2018
Annette B Vogel, David C Busse, Mario Perkovic   +2 more
exaly  

The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

ACS Nano, 2019
Anna K Blakney, Paul F Mckay, Robin J Shattock   +2 more
exaly  

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

Molecular Therapy, 2019
Connie S Schmaljohn, Andrew J Geall, Lesley C Dupuy   +2 more
exaly  

Self-amplifying RNA—opportunities and challenges

Nucleic Acid Insights
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Investigating alternative delivery systems for self-Amplifying RNA vaccines

2019
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Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

Journal of Infectious Diseases, 2015
Petra Mooij, Gerrit Koopman, Luis A Brito   +2 more
exaly  

Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity

Journal of Controlled Release
Anna K Blakney
exaly  

Vaccines: Self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?

Nature reviews. Drug discovery, 2012
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