Results 61 to 70 of about 177,835 (279)

1,1′-{[3,5-Bis(dodecyloxycarbonyl)-4-(naphthalen-2-yl)-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis{4-[(E)-2-(naphthalen-2-yl)vinyl]pyridin-1-ium}dibromide

Molbank, 2022
Synthesis of a double-charged cationic amphiphilic 1,4-dihydropyridine derivative with dodecyl ester groups at positions 3 and 5 of the 1,4-DHP ring was performed starting from Hantzsch type cyclization of dodecyl acetoacetate, 2-naphthaldehyde and ...
Martins Rucins, Martins Kaukulis, Aiva Plotniece, Karlis Pajuste, Nadiia Pikun, Arkadij Sobolev   +5 more
doaj   +1 more source

Higher and lower supramolecular orders for the design of self-assembled heterochiral tripeptide hydrogel biomaterials [PDF]

, 2015
The self-assembly behaviour of the eight stereoisomers of Val\u2013Phe\u2013Phe tripeptides under physiological conditions is assessed by several spectroscopy and microscopy techniques.
Easton, C. D., Marchesan, S., Styan, K. E., Vargiu, A. V., Waddington. L   +4 more
core   +1 more source

Self-assembly properties of a model RING domain [PDF]

Proceedings of the National Academy of Sciences, 2002
RING domains act in a variety of essential cellular processes but have no general function ascribed to them. Here, we observe that purified arenaviral protein Z, constituted almost entirely by its RING domain, self-assembles in vitro into spherical structures that resemble functional bodies formed by Z in infected ...
Alex, Kentsis, Ronald E, Gordon, Katherine L B, Borden   +2 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis [PDF]

, 2016
Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-
Cano Garrido, Olivia, Cespedes, Maria Virtudes, Cubarsí Morera, Rafael, García Fruitós, Elena, Roldan, Monica, Unzueta, Ugutz, Vazquez Gómez, Esther, Villaverde Corrales, Antonio Pedro   +7 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mechanics and kinetics of dynamic instability

eLife, 2020
During dynamic instability, self-assembling microtubules (MTs) stochastically alternate between phases of growth and shrinkage. This process is driven by the presence of two distinct states of MT subunits, GTP- and GDP-bound tubulin dimers, that have ...
Thomas CT Michaels, Shuo Feng, Haiyi Liang, L Mahadevan   +3 more
doaj   +1 more source

A tractable genotype-phenotype map for the self-assembly of protein quaternary structure

, 2013
The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here we introduce a rich, intuitive, and biologically realistic genotype-phenotype (GP) map, that serves as a model of self-assembling biological ...
Ahnert, Sebastian E., Greenbury, Sam F., Johnston, Iain G., Louis, Ard A.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Molecular Screening for Terahertz Detection with Machine-Learning-Based Methods

Physical Review X, 2021
The molecular requirements are explored for achieving efficient signal up-conversion in a recently developed technique for terahertz (THz) detection based on molecular optomechanics.
Zsuzsanna Koczor-Benda, Alexandra L. Boehmke, Angelos Xomalis, Rakesh Arul, Charlie Readman, Jeremy J. Baumberg, Edina Rosta   +6 more
doaj   +1 more source