Results 31 to 40 of about 918,480 (266)
Disaster Risk Reduction for Sustainable Development Goals [PDF]
European Project Management Journal, 2017 Our civilization is witnessing the devastating power of natural disasters all over the world. Unfortunately, it is evident that the number and intensity of disasters increased over time. Consequently, grate number of victims and material damage force the
Nataša Petrović +2 more
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Implantable device actuated by manual button clicks for noninvasive self‐drug administration
Bioengineering & Translational Medicine, 2023 Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence.
Cho Rim Kim +11 more
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eLife, 2022 Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence.
Xiaojie Liu +10 more
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Exercise decreases speedball self-administration [PDF]
Life Sciences, 2014 Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids.
Ryan T, Lacy +4 more
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Self-Administration of Toluene Vapor in Rats
Frontiers in Neuroscience, 2020 Inhalants, including volatile organic solvents such as toluene, continue to be one of the most prevalent, and often first substances abused by adolescents.
Kevin M. Braunscheidel +3 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Decentralizacja – podstawowe zagadnienia teoretyczne
Politeja, 2022 DECENTRALIZATION: BASIC THEORETICAL ISSUES The article examines decentralization as a feature of organizational structures. In order to show the complexity of decentralization, the analysis comprises four perspectives. In the subject perspective, the
Dominik Siekulicki
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