Results 41 to 50 of about 7,194,541 (265)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Errors in insulin administration reported by people with diabetes mellitus at home [PDF]

Revista Gaúcha de Enfermagem
Objective: to identify errors related to insulin administration reported by people with diabetes mellitus at home. Method: cross-sectional study, conducted at an endocrinology service in Fortaleza, from August 2022 to February 2023.
Marilia Araripe Ferreira, Virna Ribeiro Feitosa Cestari, Paulo Weslen Carneiro Gonçalves, Raquel Rodrigues da Costa Brilhante, Carla Cristina de Sordi, Débora Lira Correia, Vanessa de Araujo Lima Freire, Sherida Karanini Paz de Oliveira   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Association between self-regulatory modes and alexithymia mediated by mindfulness and cognitive reappraisal

Scientific Reports
This research examined alexithymia through the lens of personality as a dynamic regulatory system and focused on the ways in which two distinct self-regulatory modes, assessment and locomotion, are linked to alexithymia.
Idit Shalev, Erez Yaakobi
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Comparative analysis of ruminal and fecal microbiomes in Holstein, Jersey, and Jeju Black cattle using multiple taxonomic classifiers

Animal Biotechnology
The gastrointestinal microbiome is pivotal to nutrient utilization and productivity in dairy cattle. This study compared the ruminal and fecal microbiomes of Holstein, Jersey, and Jeju Black cattle using 16S rRNA gene sequencing and three taxonomic ...
Eun Tae Kim, Seung-Eun Lee, Sang-Min Shin, Dong-Hyun Lim, Tai-Young Hur, Sang-Bum Kim, Myeong-Gwan Oh, Wanho Jo, Woohyung Lee, Tansol Park   +9 more
doaj   +1 more source

The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats.

PLoS ONE, 2020
Under paradigms of combined intravenous cocaine and ethanol self-administration, the effects on behavior have been poorly explored. Numerous studies have found sex differences in amino acids profile and behavioral responses to each drug, yet few have ...
Alberto Marcos, Mario Moreno, Javier Orihuel, Marcos Ucha, Ana Mª de Paz, Alejandro Higuera-Matas, Roberto Capellán, Antonio L Crego, María-Rosa Martínez-Larrañaga, Emilio Ambrosio, Arturo Anadón, Arturo Anadón   +11 more
doaj   +1 more source

Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. [PDF]

PLoS ONE, 2017
Methamphetamine (METH) is a psychostimulant that exhibits significant abuse potential. Although METH addiction is a major health and societal concern, no drug is currently approved for its therapeutic management.
Amanda L Sharpe, Erika Varela, Michael J Beckstead   +2 more
doaj   +1 more source

'Genre blurring' in public administration: what can we learn from the humanities [PDF]

, 2014
This article seeks to broaden the craft of public administration by ‘blurring genres’. First, I explain the phrase ‘blurring genres’. Second, I provide some examples of early work in administrative ethnography.
Rhodes, R.A.W., Rhodes, Rod, R. A. W. Rhodes   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source