Locomotor activity: A distinctive index in morphine self-administration in rats. [PDF]
, 2017 Self-administration of addictive drugs is a widely used tool for studying behavioral, neurobiological, and genetic factors in addiction. However, how locomotor activity is affected during self-administration of addictive drugs has not been extensively ...
Qingyao Kong +3 more
core +1 more source
Oxycodone self-administration in male and female rats
Psychopharmacology, 2017 Oxycodone is one of the most widely prescribed painkillers in the USA. However, its use is complicated by high abuse potential. As sex differences have been described in drug addiction, the present study tested for sex differences in intravenous ...
M. Mavrikaki +4 more
semanticscholar +1 more source
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency
Journal of Controlled Release, 2021 The efficacy of RNA-based vaccines has been recently demonstrated, leading to the use of mRNA-based COVID-19 vaccines. The application of self-amplifying mRNA within these formulations may offer further enhancement to these vaccines, as self-amplifying ...
Giulia Anderluzzi +10 more
semanticscholar +1 more source
Molecular Psychiatry, 2017 Preclinical evidence suggests that ghrelin, a peptide synthesized by endocrine cells of the stomach and a key component of the gut–brain axis, is involved in alcohol seeking as it modulates both central reward and stress pathways.
M. Farokhnia +12 more
semanticscholar +1 more source
The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration [PDF]
, 2013 It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, respectively.
Bird, Judith (11691292), Bird, Judith
core +1 more source
Frontiers in Physiology, 2017 Rationale: Discordant alternans, a phenomenon in which the action potential duration (APDs) and/or intracellular calcium transient durations (CaDs) in different spatial regions of cardiac tissue are out of phase, present a dynamical instability for ...
Ilija Uzelac +7 more
doaj +1 more source
The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. [PDF]
PLoS ONE, 2017 The orexin/hypocretin system is important for appetitive motivation towards multiple drugs of abuse, including nicotine. Both OX1 and OX2 receptors individually have been shown to influence nicotine self-administration and reinstatement.
Shaun Yon-Seng Khoo +2 more
doaj +1 more source
Lorcaserin suppresses oxycodone self-administration and relapse vulnerability in rats
ACS Chemical Neuroscience, 2017 Opioid use disorder (OUD) is a major public health problem. High relapse rates and poor treatment retention continue to pose major challenges in OUD treatment.
H. Neelakantan +8 more
semanticscholar +1 more source
Three-way ANOVA calculated to evaluate the effect of maternal separation on cocaine-self-administration. [PDF]
, 2017 Three-way ANOVA calculated to evaluate the effect of maternal separation on cocaine-self-administration.
M. Victoria Milanés (117091) +5 more
core +1 more source
Ukrainian Post-Communist Transformation: Causes, Consequences and Threats
Quaestiones Geographicae, 2014 The post-communist transformation of Ukraine differs significantly from that of other countries of Central and Eastern Europe. First of all, Ukraine’s transition from totalitarianism to democracy has been long and still remains uncompleted.
Kuczabski Aleksander, Michalski Tomasz
doaj +1 more source