Results 41 to 50 of about 14,971 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists [PDF]

Neuropsychopharmacology, 2012
Sigma(1) receptors (σ(1)Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ(1)R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course of 28 experimental sessions, which was ...
Takato, Hiranita, Maddalena, Mereu, Paul L, Soto, Gianluigi, Tanda, Jonathan L, Katz   +4 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Role for Sigma Receptors in Stimulant Self Administration and Addiction

Pharmaceuticals, 2011
Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs translocate from the mitochondria-associated membrane to the cell nucleus or cell membrane, and through protein-protein interactions
Shang-Yi Tsai, Theresa Kopajtic, Takato Hiranita, Teruo Hayashi, Gianluigi Tanda, Jonathan L. Katz, Tsung-Ping Su   +6 more
doaj   +1 more source

STIMULUS CONTROL OF COCAINE SELF‐ADMINISTRATION [PDF]

Journal of the Experimental Analysis of Behavior, 2003
Environmental stimuli that set the occasion wherein drugs are acquired can “trigger” drug‐related behavior. Investigating the stimulus control of drug self‐administration in laboratory animals should help us better understand this aspect of human drug abuse.
Stanley J, Weiss, David N, Kearns, Scott I, Cohn, Charles W, Schindler, Leigh V, Panlilio   +4 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. [PDF]

PLoS ONE, 2017
Methamphetamine (METH) is a psychostimulant that exhibits significant abuse potential. Although METH addiction is a major health and societal concern, no drug is currently approved for its therapeutic management.
Amanda L Sharpe, Erika Varela, Michael J Beckstead   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Comparative analysis of ruminal and fecal microbiomes in Holstein, Jersey, and Jeju Black cattle using multiple taxonomic classifiers

Animal Biotechnology
The gastrointestinal microbiome is pivotal to nutrient utilization and productivity in dairy cattle. This study compared the ruminal and fecal microbiomes of Holstein, Jersey, and Jeju Black cattle using 16S rRNA gene sequencing and three taxonomic ...
Eun Tae Kim, Seung-Eun Lee, Sang-Min Shin, Dong-Hyun Lim, Tai-Young Hur, Sang-Bum Kim, Myeong-Gwan Oh, Wanho Jo, Woohyung Lee, Tansol Park   +9 more
doaj   +1 more source