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Role of Semaphorin 3A in Kidney Development and Diseases

Role of Semaphorin 3A in Kidney Development and Diseases
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving ...
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Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells. [PDF]

Nat Commun
Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V.   +27 more
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Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease (GSD) mouse model. [PDF]

J Zhejiang Univ Sci B
Zhang D, Xu H, Qin C, Cai K, Zhang J, Xia X, Bi J, Zhang L, Xing L, Liang Q, Wang W.   +10 more
europepmc   +1 more source

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The role of Semaphorin 3A in oral diseases

Oral Diseases, 2023
AbstractSemaphorin 3A (SEMA3A), also referred to as H‐Sema III, is a molecule with significant biological importance in regulating physiological and pathological processes. However, its role in oral diseases, particularly its association with inflammatory immunity and alveolar bone remodeling defects, remains poorly understood.
Xinyue Zhang, Zhenqi Yang, Demao Zhang, Mingru Bai   +3 more
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Osteoprotection by semaphorin 3A

Nature, 2012
The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates both osteoclasts and osteoblasts ...
Mikihito, Hayashi, Tomoki, Nakashima, Masahiko, Taniguchi, Tatsuhiko, Kodama, Atsushi, Kumanogoh, Hiroshi, Takayanagi   +5 more
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Semaphorin 3A: an immunoregulator in systemic sclerosis

Rheumatology International, 2015
Semaphorin 3A (sema3A) plays a regulatory role in immune responses, mainly affecting the activation of regulatory T cells. It has been found to correlate with disease activity in rheumatoid arthritis and systemic lupus erythematosus (SLE). To investigate the expression of sema3A in patients with systemic sclerosis (SSc) compared to healthy controls and
Doron, Rimar, Yuval, Nov, Itzhak, Rosner, Gleb, Slobodin, Michael, Rozenbaum, Katy, Halasz, Tharwat, Haj, Nizar, Jiries, Lisa, Kaly, Nina, Boulman, Zahava, Vadasz   +10 more
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The Role Of Semaphorin 3A In The Skeletal System

Critical Reviews in Eukaryotic Gene Expression, 2015
Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone ...
Peifu, Tang, Pengbin, Yin, Houchen, Lv, Licheng, Zhang, Lihai, Zhang   +4 more
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The Responsiveness of Thymic Stromal Cells to semaphorin-3A

Immunological Investigations, 2020
The thymus is responsible for thymocyte differentiation into immunocompetent T lymphocytes. Different cell types in the thymic microenvironment actively cooperate in this process, interacting with the developing thymocytes through soluble factors, extracellular matrix (ECM) molecules, and receptors.
Marvin Paulo Lins, Návylla Candeia Medeiros, Julianderson Carmo, Felipe Lima Porto, Maria Danielma dos Santos Reis, Salete Smaniotto   +5 more
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Localization of semaphorin 3A in the rat cornea

Experimental Eye Research, 2008
Semaphorin 3A (Sema3A) functions to guide the growth of neurons during development. We investigated the localization of Sema3A in the cornea, one of the most sensitive tissues in the body. Immunoblot analysis and reverse transcription-polymerase chain reaction analysis revealed that Sema3A protein and mRNA are expressed in the normal rat cornea ...
Naoyuki, Morishige, Ji-Ae, Ko, Yang, Liu, Tai-Ichiro, Chikama, Teruo, Nishida   +4 more
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Semaphorin-3A: a promising therapeutic tool in allergic rhinitis

Immunologic Research, 2022
Semaphorin-3A (Sema-3A), a secreted member of the semaphorin family, is well known for playing regulatory functions at all stages of the immune response. Sema-3A transduces signals by binding to its cognate receptors, namely, class A plexins (Plxns A1 to A4) and neuropilin-1 (Nrp-1).
Ramin Lotfi, Nahid Zamanimehr
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