Results 171 to 180 of about 234,767 (218)

The Role Of Semaphorin 3A In The Skeletal System

Critical Reviews in Eukaryotic Gene Expression, 2015
Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone ...
Peifu, Tang, Pengbin, Yin, Houchen, Lv, Licheng, Zhang, Lihai, Zhang   +4 more
openaire   +2 more sources

Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model [PDF]

Journal of Cranio-Maxillo-Facial Surgery, 2019
Purpose: This study investigates the effects of semaphorin 3A on new bone formation in an experimental rat ...
Mert Ocak, Mustafa Ramazanoglu, Seyhun Solakoğlu   +2 more
exaly   +2 more sources

Semaphorin 3A levels in vascular and nonvascular phenotypes in systemic sclerosis.

Laboratoriums Medizin, 2023
OBJECTIVE Semaphorin 3A (Sema3A) plays a regulatory role in immune responses. The aim of this study was to evaluate Sema3A levels in patients with systemic sclerosis (SSc), especially in major vascular involvements such as digital ulcer (DU), scleroderma
M. Kayaalp, A. Erden, H. Apaydın, S. Güven, B. Armağan, Merve Cağlayan Kayaalp, Esma Andac Uzdogan, Şeymanur Ala Enli, A. Omma, O. Kucuksahin   +9 more
semanticscholar   +1 more source

Localization of semaphorin 3A in the rat cornea

Experimental Eye Research, 2008
Semaphorin 3A (Sema3A) functions to guide the growth of neurons during development. We investigated the localization of Sema3A in the cornea, one of the most sensitive tissues in the body. Immunoblot analysis and reverse transcription-polymerase chain reaction analysis revealed that Sema3A protein and mRNA are expressed in the normal rat cornea ...
Naoyuki, Morishige, Ji-Ae, Ko, Yang, Liu, Tai-Ichiro, Chikama, Teruo, Nishida   +4 more
openaire   +2 more sources

The Responsiveness of Thymic Stromal Cells to semaphorin-3A

Immunological Investigations, 2020
The thymus is responsible for thymocyte differentiation into immunocompetent T lymphocytes. Different cell types in the thymic microenvironment actively cooperate in this process, interacting with the developing thymocytes through soluble factors, extracellular matrix (ECM) molecules, and receptors.
Marvin Paulo Lins, Návylla Candeia Medeiros, Julianderson Carmo, Felipe Lima Porto, Maria Danielma dos Santos Reis, Salete Smaniotto   +5 more
openaire   +2 more sources

Semaphorin 3A Confers Protection against Oxidative Stress-induced Damage in Periodontal Ligament Stem Cells through the Activation of the Wnt/β-catenin Signaling Pathway.

Current Stem Cell Research & Therapy
OBJECTIVES The osteogenic potential of periodontal ligament stem cells (PDLSCs) is crucial for periodontal tissue regeneration. Prolonged and excessive oxidative stress (OS) impairs the osteogenic function of PDLSCs.
Haipeng He, Xueshun Yuan, Yanyan Chen, Tianyong Hu, Baohui Cheng, Ruitian Du, Jiamin Huang, Xiaorui Geng, Hongwen Li, Senqing Liu, Zhiqiang Liu   +10 more
semanticscholar   +1 more source

Sodium Valproate Enhances Semaphorin 3A-mediated Anti-angiogenesis and Tumor Growth Inhibition in Human Osteosarcoma Cells

Anticancer Research, 2023
Background/Aim: Class 3 semaphorins, including semaphorin 3A (SEMA3A), are known endogenous angiogenesis inhibitors associated with endothelial cell migration and proliferation, and have been identified in many cancer cells.
T. Sawai, K. Yamanegi, H. Nishiura, H. Futani, T. Tachibana   +4 more
semanticscholar   +1 more source

Semaphorin 3A is a chemoattractant for cortical apical dendrites

Nature, 2000
The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pial surface is regulated by a diffusible chemoattractant present at high levels near the marginal zone. A major component of this signal is semaphorin 3A (Sema3A)
F, Polleux, T, Morrow, A, Ghosh
openaire   +2 more sources

Semaphorin 3A expression in the colon of Hirschsprung disease

Birth Defects Research Part A: Clinical and Molecular Teratology, 2011
AbstractBACKGROUNDHirschsprung disease (HSCR) is a congenital disorder characterized by an absence of intrinsic ganglion cells in the nerve plexuses of the lower colon. The Semaphorin 3A (SEMA3A) gene is involved in the migration of enteric neural precursors (ENPs).
Li-Li, Wang, Yang, Fan, Feng-Hua, Zhou, Hui, Li, Yi, Zhang, Jia-Ning, Miao, Hui, Gu, Tian-Chu, Huang, Zheng-Wei, Yuan   +8 more
openaire   +2 more sources

Regulation of dendritic length and branching by semaphorin 3A

Journal of Neurobiology, 2004
AbstractThe molecular mechanisms that control dendritic development are still unclear. Semaphorin 3A, a class III semaphorin, has been shown to regulate the radial orientation of pyramidal neurons in the developing neocortex. Here, we investigate the effects of Sema3A on the development of dendritic topology.
Vivian, Fenstermaker, Yachi, Chen, Anirvan, Ghosh, Rafael, Yuste   +3 more
openaire   +2 more sources