Results 171 to 180 of about 117,092 (200)

Semaphorin 3A is a chemoattractant for cortical apical dendrites

Nature, 2000
The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pial surface is regulated by a diffusible chemoattractant present at high levels near the marginal zone. A major component of this signal is semaphorin 3A (Sema3A)
F, Polleux, T, Morrow, A, Ghosh
openaire   +2 more sources

Semaphorin 3A expression in the colon of Hirschsprung disease

Birth Defects Research Part A: Clinical and Molecular Teratology, 2011
AbstractBACKGROUNDHirschsprung disease (HSCR) is a congenital disorder characterized by an absence of intrinsic ganglion cells in the nerve plexuses of the lower colon. The Semaphorin 3A (SEMA3A) gene is involved in the migration of enteric neural precursors (ENPs).
Li-Li, Wang, Yang, Fan, Feng-Hua, Zhou, Hui, Li, Yi, Zhang, Jia-Ning, Miao, Hui, Gu, Tian-Chu, Huang, Zheng-Wei, Yuan   +8 more
openaire   +2 more sources

Regulation of dendritic length and branching by semaphorin 3A

Journal of Neurobiology, 2004
AbstractThe molecular mechanisms that control dendritic development are still unclear. Semaphorin 3A, a class III semaphorin, has been shown to regulate the radial orientation of pyramidal neurons in the developing neocortex. Here, we investigate the effects of Sema3A on the development of dendritic topology.
Vivian, Fenstermaker, Yachi, Chen, Anirvan, Ghosh, Rafael, Yuste   +3 more
openaire   +2 more sources

Overexpression of semaphorin 3A in patients with urothelial cancer

Urologic Oncology: Seminars and Original Investigations, 2018
A highly sensitive and specific urine marker for the detection of recurrent urothelial cancer and for screening healthy population or people at risk for urothelial cancer has not been found yet. As urine cytology is not sensitive enough, patients with non-muscle-invasive bladder cancer need lifelong follow-up involving multiple invasive cystoscopies ...
Zahava, Vadasz, Jacob, Rubinstein, Jacob, Bejar, Hilla, Sheffer, Sarel, Halachmi   +4 more
openaire   +2 more sources

Emerging role of semaphorin-3A in autoimmune diseases

Inflammopharmacology, 2018
Autoimmune diseases (ADs) are featured by the body's immune responses being directed against its own tissues, resulting in prolonged inflammation and subsequent tissue damage. Currently, the exact pathogenesis of ADs remains not fully elucidated. Semaphorin-3A (Sema3A), a secreted member of semaphorin family, is a potent immunoregulator during all ...
Li-Na, Liu, Xiao-Mei, Li, Dong-Qing, Ye, Hai-Feng, Pan   +3 more
openaire   +2 more sources

Semaphorin 3A on Osteoporosis: An Overreview of the Literature

Calcified Tissue International
Semaphorin 3A (Sema3A) is a signaling protein that has attracted increasing attention in recent years for its important role in regulating bone metabolism. In this review, we searched different databases with various combinations of keywords to analyze the effects of Sema3A on osteoporosis. Sema3A promotes bone formation and inhibits bone resorption by
Yueyi Zhang, Hanfen Shi, Xuan Dai, Jin Shen, Jiyuan Yin, Tianshu Xu, Gaiyue Yue, Haochen Guo, Ruiqiong Liang, Qishuang Chen, Sihua Gao, Lili Wang, Dongwei Zhang   +12 more
openaire   +2 more sources

Semaphorin 3A: Is a key player in the pathogenesis of asthma

Clinical Immunology, 2017
Immune semaphorins are key players in regulating immune mediated inflammation. Semaphorin3A (sema3A) a secreted and membrane bound member of this family, is well reported for its properties in maintaining self-tolerance. Semaphorin3A was recognized to be a marker for T-regulatory cells (Tregs), and as such is a useful tool for assessing the status of ...
Ronen, Cozacov, Katlin, Halasz, Tharwat, Haj, Zahava, Vadasz   +3 more
openaire   +2 more sources

Age-Dependent Effects of Secreted Semaphorins 3A, 3F, and 3E on Developing Hippocampal Axons: In Vitro Effects and Phenotype of Semaphorin 3A (−/−) Mice

Molecular and Cellular Neuroscience, 2001
We studied the role of Semaphorins in the formation of hippocampal connections at embryonic and early postnatal stages. We show that the embryonic entorhinal cortex has a repulsive effect on embryonic hippocampal axons that disappears gradually at postnatal stages. Such chemorepulsion is blocked by Neuropilin-1 and -2 blocking antibodies.
E, Pozas, M, Pascual, K T, Nguyen Ba-Charvet, P, Guijarro, C, Sotelo, A, Chédotal, J A, Del Río, E, Soriano   +7 more
openaire   +2 more sources

Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

Cell, 2020
Hunsang Lee, Greg L Beilhartz, Iga Kucharska   +2 more
exaly  

Structural basis of semaphorin‐plexin cis interaction

EMBO Journal, 2020
Daniel Rozbeský, Dimple Karia, Gergely N Nagy   +2 more
exaly