Results 71 to 80 of about 8,554 (168)

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Nature Communications, 2019
Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand ...
Marine Leclerc, Elodie Voilin, Gwendoline Gros, Stéphanie Corgnac, Vincent de Montpréville, Pierre Validire, Georges Bismuth, Fathia Mami-Chouaib   +7 more
doaj   +1 more source

Overcoming Barriers to Axonal Regeneration in Spinal Cord Injury: Mechanistic Insights and Therapeutic Frontiers

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This review summarizes the key intrinsic and extrinsic barriers to axonal regeneration after spinal cord injury and outlines current strategies to rebuild a growth‐permissive microenvironment and enhance neuronal regenerative capacity. ABSTRACT Background Spinal cord injury (SCI) is a devastating central nervous system disorder that often causes ...
Jiaxin Gao, Tian Li, Qingping Su, Cai Jiang, Zhonghua Lin   +4 more
wiley   +1 more source

De Novo Genome Assemblies of Four Rainbow Trout Genetic Lines Reveal Structural Variants in Pursuit of a Pangenome Reference

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Rainbow trout (Oncorhynchus mykiss) exhibit extensive genomic diversity shaped by domestication, life history and geographic origin. To advance the development of a comprehensive pangenome reference, we present new de novo genome assemblies of two genetically and ecologically distinct lines: Whale Rock (WR; wild, landlocked, Central California)
Ali Ali, Geoffrey C. Waldbieser, Ramey C. Youngblood, Paul A. Wheeler, Brian E. Scheffler, Stuart Willis, Shawn R. Narum, Gary H. Thorgaard, Mohamed Salem, Yniv Palti   +9 more
wiley   +1 more source

Integrated Proteomic and scRNA‐Seq Analysis Reveals Pyroptosis‐Related Subtypes in Lung Adenocarcinoma

The Clinical Respiratory Journal, Volume 20, Issue 7, July 2026.
ABSTRACT Background Pyroptosis is a recently identified form of programmed cell death that plays an important role in cancer initiation and progression. However, the function of pyroptosis in lung adenocarcinoma (LUAD) remains unclear. The study integrated proteomic and single‐cell RNA sequence (scRNA‐seq) data to investigate the potential role of ...
Tianchang Wei, Yongqi Wei, Weiqi Mao, Cuiping Zhang, Jian Xu, Chunlai Lu, Yuanlin Song, Xiaoyan Chen   +7 more
wiley   +1 more source

Semaphorin 3A Signaling in Kidney Development and Diseases

, 2023
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is the secreted and membrane-associated proteins, which regulate diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving
Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada   +5 more
openaire   +1 more source

Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

International Journal of Ophthalmology, 2015
AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A) in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC) mice model induced by short ragweed pollen (SRW) in 4-week-old of BALB/c mice, mice were ...
Junmi Tanaka, Hideo Tanaka, Nobuhisa Mizuki, Eiichi Nomura, Hideo Tanaka, Naoko Nomura, Masayuki Yamane, Tomonobu Hida, Yoshio Goshima, Hiroshi Hatano, Hisashi Nakagawa   +10 more
doaj   +1 more source

Inflammation and itching in patients suffering from atopic dermatitis and psoriasis. Assessment of the expression of neurotrophins аnd neuropeptides

Vestnik Dermatologii i Venerologii, 2017
Goal. To assess the expression of neurotrophin, a nerve growth factor, amphiregulin, an epidermal growth factor, semaphorin 3A, a nerve repulsion factor, and PGP9.5 protein, a nerve fiber marker, in the skin of patients suffering from atopic dermatitis ...
V. A. Smolyannikova, A. A. Kubanova, V. V. Chikin, A. E. Karamova   +3 more
doaj   +1 more source

Expression of semaphorin‐3A in the joint and role in osteoarthritis

Cell Biochemistry and Function
AbstractOsteoarthritis (OA) is characterised by the deterioration of cartilage in the joints and pain. We hypothesise that semaphorin‐3A (sema‐3A), a chemorepellent for sensory nerves, plays a role in joint degradation and pain. We used the mechanical joint loading (MJL) model of OA to investigate sema‐3A expression in the joint and examine its ...
Xiang Li, Sara Martinez‐Ramos, Freija T. Heedge, Andrew Pitsillides, George Bou‐Gharios, Blandine Poulet, Chantal Chenu   +6 more
openaire   +2 more sources

Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets

Scientific Reports
Semaphorins were initially identified as axon guidance molecules that were widely expressed and involved in divergent functions in various organs, including neuronal development and immunological processes.
Mayu Kyohara, Rie Takayanagi, Takahiro Tsuno, Esther Ong Yajima, Ryota Inoue, Naoya Yamashita, Tomoko Okuyama, Kuniyuki Nishiyama, Kohichi Matsunaga, Emi Ishida, Shuichi Ito, Yasuo Terauchi, Yoshio Goshima, Jun Shirakawa   +13 more
doaj   +1 more source

Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A

Stem Cells International, 2012
In human skeletal muscle, myoblasts represent the main population of myogenic progenitors. We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineages, some ...
Séverine Lecourt, Yves Lepelletier, Valérie Vanneaux, Rafika Jarray, Thomas Domet, Françoise Raynaud, Réda Hadj-Slimane, Audrey Cras, Olivier Hermine, Jean-Pierre Marolleau, Jérôme Larghero   +10 more
doaj   +1 more source