Results 151 to 160 of about 910 (176)
VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation
Developmental Biology, 2009 Sympathetic nerve activity regulates blood pressure by altering peripheral vascular resistance. Variations in vascular sympathetic innervation suggest that vascular-derived cues promote selective innervation of particular vessels during development. As axons extend towards peripheral targets, they migrate along arterial networks following gradients of ...
Steven M Jay +2 more
exaly +4 more sources
Developmental guidance of embryonic corneal innervation: Roles of Semaphorin3A and Slit2
Developmental Biology, 2010 The cornea is one of the most densely innervated structures of the body. In the developing chicken embryo, nerves from the ophthalmic trigeminal ganglion (OTG) innervate the cornea in a series of spatially and temporally regulated events. However, little is known concerning the signals that regulate these events.
Thomas F Linsenmayer
exaly +4 more sources
Semaphorin3a disrupts podocyte foot processes causing acute proteinuria [PDF]
Kidney International, 2008 Semaphorin3a was discovered as a secreted guidance protein that acts as a chemorepellent to migrating axons and endothelial cells. In the adult mouse kidney, it is expressed in podocytes and collecting tubules. Here, we show that exogenous semaphorin3a caused acute nephrotic range proteinuria associated with podocyte foot process effacement and fusion,
Tapia, R. +5 more
exaly +4 more sources
Cell Reports, 2021 In the mammalian cerebral cortex, the developmental events governing allocation of different classes of inhibitory interneurons (INs) to distinct cortical layers are poorly understood.
Greta Limoni +2 more
exaly +2 more sources
Developmental Biology, 2000 Semaphorin3A (previously known as Semaphorin III, Semaphorin D, or collapsin-1) is a member of the semaphorin gene family, many of which have been shown to guide axons during nervous system development.
Fletcher A White, Oded BÉHAR
exaly +2 more sources
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Effects of Semaphorin3A on the growth of sensory and motor neurons
Experimental Cell Research, 2023After peripheral nerve injury, motor and sensory axons can regenerate, but the inaccurate reinnervation of the target leads to poor functional recovery. Schwann cells (SCs) express sensory and motor phenotypes associated with selective regeneration. Semaphorin 3A (Sema3A) is an axonal chemorepellent that plays an essential role in axon growth.
Mi Shen +7 more
openaire +2 more sources
mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling
Biochemical and Biophysical Research Communications, 2016Aberration of signaling pathways by genetic mutations or alterations in the surrounding tissue environments can result in tumor development or metastasis. However, signaling molecules responsible for these processes have not been completely elucidated. Here, we used mouse Lewis lung carcinoma cells (LLC) to explore the mechanism by which the oncogenic ...
Daisuke Yamada +2 more
exaly +3 more sources
Semaphorin3A regulates mitochondrial apoptosis in RAW264.7 cells in vitro
Tissue and Cell, 2022Osteoclasts apoptosis plays vital roles in abnormal bone remodeling-associated diseases. It's reported that Semaphorin3A (Sema3A) may affect osteoarthritis progression through osteoclasts function, while the specific mechanism remains unclear. To determine the effect of Sema3A on osteoclasts, we detected the apoptosis of RAW264.7 cells treated with ...
Zhongkui, Guo +6 more
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Development of the corticospinal tract in Semaphorin3A- and CD24-deficient mice
Neuroscience, 2007Mutations in the gene encoding the neural recognition molecule L1 result in hypoplasia of the corticospinal tract and path finding errors of corticospinal axons at the pyramidal decussation. Candidate molecules that have been implicated in L1-dependent guidance of corticospinal axons from the ventral medullary pyramids to the contralateral dorsal ...
Masaru Taniguchi, Melitta Schachner
exaly +4 more sources
Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits
Clinical Oral Investigations, 2021In the present study, we intend to assess the function of Sema3A in osteointegration of titanium implants both in vivo and in vitro.Briefly, Sema3A was transfected in HBMSCs cells to detect its effect on osteogenesis. Subsequently, an in vivo rabbit model was established.
An Song +8 more
openaire +2 more sources