Results 91 to 100 of about 9,266 (196)

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Nature Communications, 2019
Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand ...
Marine Leclerc, Elodie Voilin, Gwendoline Gros, Stéphanie Corgnac, Vincent de Montpréville, Pierre Validire, Georges Bismuth, Fathia Mami-Chouaib   +7 more
doaj   +1 more source

High‐dimensional multiomics reveals perturbations to IL‐6/IL‐6R axis and RUNX3 in CD4+ T cells during third‐trimester pregnancy

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives CD4+ T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4+ T‐cell surface proteome and transcriptome during pregnancy. Methods CD4+ T cells were analysed in blood and decidua from term pregnancies (> 37 weeks) and non‐pregnant blood.
Jennifer R Habel, Thi H O Nguyen, Natasha de Alwis, E Kaitlynn Allen, Shihan Li, Morgan J Skinner, Jennifer A Juno, Stephen J Kent, Katherine Bond, Deborah A Williamson, Martha Lappas, Natalie J Hannan, Susan Walker, Jan Schroeder, Jeremy Chase Crawford, Paul G Thomas, Katherine Kedzierska, Louise C Rowntree   +17 more
wiley   +1 more source

Semaphorin 3A Signaling in Kidney Development and Diseases

, 2023
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is the secreted and membrane-associated proteins, which regulate diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving
Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada   +5 more
openaire   +1 more source

Recent Advances in Natural Polymers‐based Hydrogels for Periodontal Regeneration

Macromolecular Bioscience, Volume 26, Issue 5, May 2026.
Natural polymer‐based hydrogels are emerging as promising biomimetic platforms for periodontal regeneration. This review highlights advances in alginate, collagen, and chitosan hydrogels engineered to modulate inflammation, deliver bioactive agents, and support tissue repair.
João de Freitas Gomes Neto, Tainara de Paula de Lima Lima, Luiza Meurer Brand, Caio Fernando Cardoso Souza, Marcelo Lazzaron Lamers, Pedro L. Granja, Luiz Antonio Pessan, Eduardo Henrique Backes   +7 more
wiley   +1 more source

Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function

, 2006
An important aspect of tumor progression is the ability of cancer cells to escape detection and clearance by the immune system. Recent studies suggest that several tumors express soluble factors interfering with the immune response.
Tamagnone, Luca
core   +1 more source

Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Synapses are implicated in several neurological disorders and psychiatric diseases. The emergence and wide use of neural organoids provide a new opportunity to study human synapses in healthy and disease settings. Therefore, we developed a simple method for the enrichment of synaptosomes and growth cone particles from forebrain organoids. The method is
Marie S. Øhlenschlæger, Lucrezia Criscuolo, Pia Jensen, Daniel J. Lloyd‐Davies Sánchez, Magdalena Sutcliffe, Santosh Bhosale, Helle Bogetofte, Muhammad Tahir, Lene A. Jakobsen, Maria Pihl, Jonathan Brewer, Veit Schwämmle, Frantz R. Poulsen, Kristine Freude, Madeline A. Lancaster, Phillip J. Robinson, Martin R. Larsen   +16 more
wiley   +1 more source

Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1

, 2013
SummaryThe deterioration of the inner blood-retinal barrier and consequent macular edema is a cardinal manifestation of diabetic retinopathy (DR) and the clinical feature most closely associated with loss of sight. We provide evidence from both human and
Leboeuf, Dominique, Binet, François, Menard, Catherine, De Guire, Vincent, Rezende, Flavio A., Sitaras, Nicholas, Miloudi, Khalil, Cerani, Agustin, Sapieha, Przemyslaw, Lapalme, Eric, Tetreault, Nicolas, Patel, Chintan, Beaudoin, Felix, Dejda, Agnieszka   +13 more
core   +1 more source

Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

International Journal of Ophthalmology, 2015
AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A) in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC) mice model induced by short ragweed pollen (SRW) in 4-week-old of BALB/c mice, mice were ...
Junmi Tanaka, Hideo Tanaka, Nobuhisa Mizuki, Eiichi Nomura, Hideo Tanaka, Naoko Nomura, Masayuki Yamane, Tomonobu Hida, Yoshio Goshima, Hiroshi Hatano, Hisashi Nakagawa   +10 more
doaj   +1 more source

Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors

, 1999
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex.
Takahashi, Takuya, Nakamura, Fumio, Murakami, Yasunori, Fournier, Alyson, Wang, Li-Hsien, Strittmatter, Stephen M., Kalb, Robert G., Fujisawa, Hajime   +7 more
core   +1 more source

Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model

, 2019
Purpose: This study investigates the effects of semaphorin 3A on new bone formation in an experimental rat ...
Onur, Özen, Firatli, Erhan, ÇELİK, HAKAN HAMDİ, Ocak, Mert, Ramazanoglu, Mustafa, Solakoglu, Seyhun, Uzuner, Bora, Kotil, Tugba, Kenan, Seving   +8 more
core   +1 more source