Results 71 to 80 of about 4,718 (156)
Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.ABSTRACT Tendinopathy is a complex, painful condition that affects up to 5% of the general population in their lifetime. Antibiotic treatment with fluoroquinolones has been associated with the onset of tendinopathy and tendon rupture. The mechanisms behind fluoroquinolone induced tendinopathy remain unclear. To probe activation of potentially causative
Nicole A. Chittim +4 more
wiley +1 more source
Plexin D1 negatively regulates zebrafish lymphatic development.
, 2023 Lymphangiogenesis is a dynamic process that involves the directed migration of lymphatic endothelial cells (LECs) to form lymphatic vessels. The molecular mechanisms that underpin lymphatic vessel patterning are not fully elucidated and, to date, no ...
Hogan, Benjamin M +13 more
core +1 more source
VIEW, Volume 7, Issue 1, February 2026.This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu +8 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 4, February 2026.Unc5A, a netrin ligand‐receptor expressed in satellite cell‐derived myoblasts, may regulate the formation of fast‐twitch myotubes by stimulating fast‐type myosin heavy chain synthesis. Abstract Myoblasts autonomously govern myofiber‐type specification of newly formed myotubes through autocrine–paracrine‐dependent manners mediated by multipotent ...
Takahiro Maeno +15 more
wiley +1 more source
Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival
, 2006 Class 3 semaphorins are guidance proteins that play crucial roles during development. Semaphorins 3A (sema 3A) and 3F are expressed by podocytes in vivo throughout ontogeny and their function is unknown.
Teichman, J. +4 more
core +1 more source
Scientific ReportsFOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35 ...
Kevin J. Tam +13 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale +6 more
wiley +1 more source
Data from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
, 2023 <div>Abstract<p>Semaphorins play important regulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses. We find that semaphorin-3C (sema3C) induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1–dependent manner, while most other ...
Gera Neufeld +3 more
openaire +1 more source
Aggregate, Volume 7, Issue 1, January 2026.This is the first case of glutathione‐depleted and responsive platinum(II) metallacycles to turn on the NIR emission simultaneously. The combination of GSH depletion and ROS generation induces oxidative stress and immunogenic cell death (ICD) in tumor cells.
Qifei Shen +12 more
wiley +1 more source
Semaphorin 3C in prostate cancer tumourigenesis
, 2017 Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a leading cause of cancer-related deaths in men. Local non-invasive PCa is highly treatable but limited treatment options exist for those with locally-advanced and ...
Tam, Kevin J.
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