Results 1 to 10 of about 2,214 (111)

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing [PDF]

Advanced Science
Penile squamous cell carcinoma (PSCC) is a rare genitourinary malignancy, and factors of its tumor microenvironment (TME) could serve as prognostic indicators for tumor recurrence and metastasis. Here, we generated a comprehensive single‐cell map of PSCC
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
doaj   +3 more sources

A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC) [PDF]

Biomedicines
Background/Objectives: Bladder cancer is a very important issue in contemporary urology. The aim of this pilot study was to assess for the first time the clinical utility of semaphorin 3C (sema3C) and 4A (sema4A) in patients with non-muscle-invasive ...
Tomasz W Kaminski, Władysław Kordan, Anna J Korzekwa   +2 more
exaly   +4 more sources

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression [PDF]

Signal Transduction and Targeted Therapy
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-associated fibroblasts (CAFs) and cancer stem
Kun Feng, Yewei Zhang, Zhang Yewei
exaly   +3 more sources

An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development. [PDF]

Genes Cells
Focusing on an OFT‐specific differentially accessible region, in the present study, we defined a distal OFT myocardial enhancer whose activity depends on GATA binding sites. This enhancer provides insight into the mechanisms underlying spatially restricted Sema3c expression involved in OFT development.
Wang Y, Harada Y, Ueyama T, Seya D, Nakagawa O, Kawamura T.   +5 more
europepmc   +2 more sources

SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment

Frontiers in Oncology, 2022
To date, driver genes for pancreatic cancer treatment are difficult to pursue therapeutically. Targeting mutated KRAS, the most renowned driver gene in pancreatic cancer, is an active area of study.
Edward J Kim, Chang-Il Hwang, Tzu-Yin Lin   +2 more
exaly   +3 more sources

Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma

Nature Communications, 2023
The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao, Haidong Huang, Jianjun Zhao
exaly   +2 more sources

Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma

Journal of International Medical Research, 2021
Objective Semaphorin 3C (Sema3C) may regulate tumor metastasis and prognosis. We determined the biological roles of Sema3C in the hepatic metastasis of gastric adenocarcinoma and evaluated its clinical significance as a potential biomarker.
Bo Ni, Gang Zhao, Hui Cao
exaly   +2 more sources

SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis

Frontiers in Oncology, 2019
Introduction: Aberrant activation of Semaphorin3C(SEMA3C) is widespread in human cancers. We aimed to analyze SEMA3C expression in cervical cancer and investigate the role of SEMA3C in cervical cancer and its underlying mechanism, which is important for ...
Ruoyan Liu, Yanjie Shuai, Jingtao Luo
exaly   +3 more sources

Tumor-stroma contributes to immunotherapeutic resistance in non-small cell lung cancer via SEMA3C-mediated immunosuppressive tumor microenvironment [PDF]

Translational Oncology
Background: The tumor-stroma proportion (TSP) was a critical factor influencing clinical outcomes in non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms driving TSP-associated aggressiveness and its contribution to immune ...
Huanyan Zhang, Hongxin Lin, Jian Wang, Di Wu, Qian Wang, Jie Mei, Qing Li, Yichao Zhu, Yun Cai   +8 more
doaj   +2 more sources

Silencing MALAT1 represses pathological progression, inflammation, and vascular smooth muscle cell phenotype switching by regulating the SEMA3C-mediated Smad pathway in intracranial aneurysms [PDF]

Frontiers in Cellular Neuroscience
BackgroundThe crucial role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in regulating aneurysm formation, inflammation, and neural dysfunction has gradually been recognized.
Junlong Kang, Junlong Kang, Wei Li, Xinjie Gao, Xinjie Gao, Xinhua Tian, Wei Feng, Xiang Yao, Feng Wei, Luyue Chen, Hongjin Chen, Junjiang Tong, E Chen, Yuxiang Gu, Yuxiang Gu, Yuxiang Gu   +15 more
doaj   +2 more sources