Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease [PDF]
Journal of International Medical Research, 2021 Objective Cluster genes, specifically the class 3 semaphorins ( SEMA3 ) including SEMA3C , have been associated with the development of Hirschsprung disease (HSCR) in Caucasian populations.
Gunadi +13 more
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Dependency of Tamoxifen Sensitive and Resistant ER+ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth [PDF]
Cells, 2023 Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ...
Satyam Bhasin +6 more
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Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells [PDF]
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
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Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression [PDF]
Signal Transduction and Targeted TherapyMore than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-associated fibroblasts (CAFs) and cancer stem
Hao Peng +4 more
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The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair. [PDF]
PLoS ONE, 2013 Lung diseases characterized by alveolar damage such as bronchopulmonary dysplasia (BPD) in premature infants and emphysema lack efficient treatments. Understanding the mechanisms contributing to normal and impaired alveolar growth and repair may identify
Arul Vadivel +6 more
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Semaphorin‐3C signals through Neuropilin‐1 and PlexinD1 receptors to inhibit pathological angiogenesis [PDF]
EMBO Molecular Medicine, 2015 Retinopathy of prematurity causes visual impairment due to destructive neoangiogenesis after degeneration of the retinal microvasculature. This study was aimed at analyzing whether local delivery of Semaphorin‐3C (Sema3C) suppresses pathological retinal ...
Wan‐Jen Yang +5 more
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Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C [PDF]
Advanced ScienceThe color patterns of mammalian fur are determined by melanocytes' ability to respond to and adapt to microenvironmental cues. However, these patterns can be lost following injury or under pathological conditions, and the underlying biological mechanisms
Tingting Li +17 more
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Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C. [PDF]
PLoS Biology, 2009 The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure ...
Mathieu Niquille +10 more
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Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]
J PatholAbstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M +8 more
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Silencing MALAT1 represses pathological progression, inflammation, and vascular smooth muscle cell phenotype switching by regulating the SEMA3C-mediated Smad pathway in intracranial aneurysms [PDF]
Frontiers in Cellular NeuroscienceBackgroundThe crucial role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in regulating aneurysm formation, inflammation, and neural dysfunction has gradually been recognized.
Junlong Kang +15 more
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