Results 41 to 50 of about 4,718 (156)

Supplementary Material for: A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics

, 2022
Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular ...
Frère P. (14308421), Cai A. (14308415), Ouchelouche S. (14308424), Calmont A. (14308430), Louedec L. (8628591), Chatziantoniou C. (14308427), Placier S. (14308418)   +6 more
core   +1 more source

A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization. [PDF]

PLoS ONE, 2016
In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC)
Shira Toledano, Huayi Lu, Agustina Palacio, Keren Ziv, Ofra Kessler, Shlomit Schaal, Gera Neufeld, Yoreh Barak   +7 more
doaj   +1 more source

Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease

Cell Death and Disease, 2023
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis underlying kidney organization involves complex cell-to-cell interaction ...
Yi-Chun Tsai, Mei-Chuan Kuo, Juan-Chi Huang, Wei-An Chang, Ling-Yu Wu, Yung-Chi Huang, Chao-Yuan Chang, Su-Chu Lee, Ya-Ling Hsu   +8 more
doaj   +1 more source

GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. [PDF]

J Clin Invest, 2006
GATA transcription factors play critical roles in restricting cell lineage differentiation during development. Here, we show that conditional inactivation of GATA-6 in VSMCs results in perinatal mortality from a spectrum of cardiovascular defects, including interrupted aortic arch and persistent truncus arteriosus.
Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS.   +5 more
europepmc   +4 more sources

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

EMBO Molecular Medicine, 2018
Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong   +24 more
doaj   +1 more source

Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development [PDF]

, 2022
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear.
Motta, A, Bonnavion, R, Paredes, I, Schermann, G, Himmels, P, Ioannou, E, Vieira, JR, Adler, H, Shah, B, Dyukova, E, Ruiz de Almodóvar, C, Fischer, A, Dupraz, S, Bradke, F, Navarro-Aragall, A, Bonanomi, D, Ruhrberg, C, Gärtner, L   +17 more
core   +3 more sources

The association of semaphorins 3C, 5A and 6D with liver fibrosis stage in chronic hepatitis C [PDF]

PLOS ONE, 2018
Semaphorins are a diverse family of immunoregulators recently recognized to play a major role in various phases of immune responses. Their role in chronic viral hepatitis C (CHC) and contribution to the progression of liver disease is unknown. The aim of this study was to analyse the association of secreted semaphorins with the severity of liver ...
Neven Papic, Snjezana Zidovec Lepej, Lana Gorenec, Ivana Grgic, Slavko Gasparov, Tajana Filipec Kanizaj, Adriana Vince   +6 more
openaire   +7 more sources

Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe small GTPase Rac1 regulates diverse cellular functions, including both apicobasal and planar cell polarity pathways; however, its role in cardiac outflow tract (OFT) development remains unknown. In the present study, we aimed to examine the
Carmen Leung, Yin Liu, Xiangru Lu, Mella Kim, Thomas A. Drysdale, Qingping Feng   +5 more
doaj   +1 more source

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption [PDF]

Development, 2001
Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3Clocus in mice by targeted mutagenesis. semaphorin 3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac
L, Feiner, A L, Webber, C B, Brown, M M, Lu, L, Jia, P, Feinstein, P, Mombaerts, J A, Epstein, J A, Raper   +8 more
openaire   +2 more sources