Results 21 to 30 of about 4,625 (132)

Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity. [PDF]

Nutrients, 2023
Regular physical activity and the use of nutritional supplements, including antioxidants, are recognized as efficacious approaches for the prevention and mitigation of obesity-related complications. This study investigated the effects of 12 weeks of CrossFit training combined with astaxanthin (ASX) supplementation on some plasma adipokines in males ...
Supriya R, Shishvan SR, Kefayati M, Abednatanzi H, Razi O, Bagheri R, Escobar KA, Pashaei Z, Saeidi A, Shahrbanian S, Bagchi S, Sengupta P, Al Kiyumi MH, Heinrich KM, Zouhal H.   +14 more
europepmc   +5 more sources

Semaphorin 3C exacerbates liver fibrosis [PDF]

, 2021
Abstract Background & Aims Chronic liver disease is a growing epidemic leading to fibrosis and cirrhosis. TGF-β is the pivotal pro-fibrogenic cytokine which activates hepatic stellate cells (HSC), yet, other molecules can substantially modulate TGF-β signaling in the course of liver fibrosis ...
Francesca De Angelis Rigotti, Lena Wiedmann, Max Ole Hubert, Margherita Vacca, Sana S. Hasan, Iris Moll, Silvia Carvajal, Wladimiro Jiménez, Maja Starostecka, Adrian T Billeter, Beat Müller-Stich, Gretchen Wolff, Bilgen Ekim-Üstünel, Stephan Herzig, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita   +16 more
openaire   +1 more source

Semaphorin 3C exacerbates liver fibrosis

Hepatology, 2023
Background and Aims: Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-β is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-β signaling during liver fibrosis.
Francesca De Angelis Rigotti, Lena Wiedmann, Max Ole Hubert, Margherita Vacca, Sana S. Hasan, Iris Moll, Silvia Carvajal, Wladimiro Jiménez, Maja Starostecka, Adrian T. Billeter, Beat Müller-Stich, Gretchen Wolff, Bilgen Ekim-Üstünel, Stephan Herzig, Cristina Fandos-Ramo, Ralph Krätzner, Maria Reich, Verena Keitel-Anselmino, Mathias Heikenwälder, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita   +21 more
openaire   +5 more sources

Association of Immune Semaphorins with COVID-19 Severity and Outcomes

Biomedicines, 2023
Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic, Neven Papic, Lara Samadan, Mirjana Balen Topic, Adriana Vince   +4 more
doaj   +1 more source

Semaphorin 3C is involved in the progression of gastric cancer. [PDF]

Cancer Sci, 2012
Malignant tumors are often associated with denervation, suggesting the functional implication of axonal guidance molecules in tumor growth. Here, we assessed the role of semaphorin 3C (sema3C) in the progression of gastric cancer. Immunohistochemistry of human samples revealed that sema3C was strongly expressed in neoplastic cells, especially at the ...
Miyato H, Tsuno NH, Kitayama J.
europepmc   +4 more sources

Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?

Biomedicines, 2022
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan, Neven Papić, Maja Mijić, Ivana Knežević Štromar, Slavko Gašparov, Adriana Vince   +5 more
doaj   +1 more source

Correlation of Peritumoral Edema and Microvessel Density with Tissue Expression of VEGF, Semaphorins 3A and 3C in Patients with Meningioma

Asian Pacific Journal of Cancer Biology, 2019
Background: Several angiogenic factors correlate with angiogenesis in meningioma while their exact role is yet to be identified. Semaphorins are described with a variety of physiological functions including angiogenesis and migration of neural crest ...
Mehdi Salimi-Sotoodeh, Arash Saffarian, Mousa Taghipour, Amir-Reza Dehghanian, Nooshafarin Chenari, Abbas Ghaderi, Mahboobeh Razmkhah   +6 more
doaj   +3 more sources

Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF-7 breast cancer cells. [PDF]

Oncol Lett, 2017
Previous studies have suggested that semaphorin 3C (SEMA3C) is involved in the tumorigenesis and metastasis of a number of types of cancer. The aim of the present study was to investigate the role of SEMA3C in the proliferation and migration of MCF-7 breast cancer cells.
Zhu X, Zhang X, Ye Z, Chen Y, Lv L, Zhang X, Hu H.   +6 more
europepmc   +4 more sources

Semaphorin 3C is a novel adipokine linked to extracellular matrix composition [PDF]

Diabetologia, 2013
Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extracellular matrix (ECM) composition, promote an insulin-resistant state. We set out to identify novel adipokines regulated by body fat mass in human subcutaneous WAT with potential roles in adipose function.Adipose transcriptome data and ...
Mejhert, N., Wilfling, F., Esteve, Daniel, Galitzky, J., Pellegrinelli, V., Kolditz, C.-I., Viguerie, N., Tordjman, J., Näslund, E., Trayhurn, P., Lacasa, D., Dahlman, I., Stich, V., Lång, P., Langin, D., Bouloumié, A., Clément, K., Rydén, Mikael   +17 more
openaire   +3 more sources

Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis [PDF]

Cancer Research, 2015
Abstract Semaphorins play important regulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses. We find that semaphorin-3C (sema3C) induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1–dependent manner, while most other ...
Yelena, Mumblat, Ofra, Kessler, Neta, Ilan, Gera, Neufeld   +3 more
openaire   +2 more sources