Results 11 to 20 of about 4,625 (132)

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]

J Pathol
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G.   +8 more
europepmc   +2 more sources

An Immune-privileged niche mediates immunotherapy resistance in esophageal carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background Neoadjuvant immunotherapy has reshaped the treatment paradigm for esophageal squamous cell carcinoma (ESCC), yet mechanisms of resistance in non-responders remain poorly understood.
Min Wang, Li Zhang, Qilong Wang, Li Wan, Xinyi Chen, Fei Xie, Boye Li, Tianyun Ma, Haotian Ge, Zixuan Xiao, Lingda Meng, Kunxin Xie   +11 more
doaj   +2 more sources

A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC) [PDF]

Biomedicines
Background/Objectives: Bladder cancer is a very important issue in contemporary urology. The aim of this pilot study was to assess for the first time the clinical utility of semaphorin 3C (sema3C) and 4A (sema4A) in patients with non-muscle-invasive ...
Piotr Purpurowicz, Tomasz W. Kaminski, Władysław Kordan, Anna Korzekwa, Zbigniew Purpurowicz, Zbigniew Jabłonowski   +5 more
doaj   +2 more sources

Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells. [PDF]

Endocr Relat Cancer, 2023
Intratumoral androgen biosynthesis contributes to castration-resistant prostate cancer progression in patients treated with androgen deprivation therapy. The molecular mechanisms by which castration-resistant prostate cancer acquires the capacity for androgen biosynthesis to bypass androgen deprivation therapy are not entirely known. Here, we show that
Yenki P, Bhasin S, Liu L, Nabavi N, Cheng CW, Tam KJ, Peacock JW, Adomat HH, Tombe T, Fazli L, Ivanova L, Dusek C, Khosravi S, Guns EST, Wang Y, Buttyan R, Gleave ME, Ong CJ.   +17 more
europepmc   +3 more sources

Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers. [PDF]

Int J Mol Sci, 2019
The semaphorins represent a large family of signaling molecules with crucial roles in neuronal and cardiac development. While normal semaphorin function pertains largely to development, their involvement in malignancy is becoming increasingly evident. One member, Semaphorin 3C (SEMA3C), has been shown to drive a number of oncogenic programs, correlate ...
Hui DHF, Tam KJ, Jiao IZF, Ong CJ.
europepmc   +5 more sources

Targeting Semaphorin 3C in Prostate Cancer With Small Molecules. [PDF]

J Endocr Soc, 2018
Despite the amenability of early-stage prostate cancer to surgery and radiation therapy, locally advanced and metastatic prostate cancer is clinically problematic. Chemical castration is often used as a first-line therapy for advanced disease, but progression to the castration-resistant prostate cancer phase occurs with dependable frequency, largely ...
Lee CCW, Munuganti RSN, Peacock JW, Dalal K, Jiao IZF, Shepherd A, Liu L, Tam KJ, Sedgwick CG, Bhasin S, Lee KCK, Gooding L, Vanderkruk B, Tombe T, Gong Y, Gleave ME, Cherkasov A, Ong CJ.   +17 more
europepmc   +4 more sources

A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics.

Nephron, 2023
Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is ...
Cai A, Placier S, Louedec L, Frère P, Ouchelouche S, Chatziantoniou C, Calmont A.   +6 more
europepmc   +3 more sources

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. [PDF]

Am J Hum Genet, 2015
Innervation of the gut is segmentally lost in Hirschsprung disease (HSCR), a consequence of cell-autonomous and non-autonomous defects in enteric neuronal cell differentiation, proliferation, migration, or survival. Rare, high-penetrance coding variants and common, low-penetrance non-coding variants in 13 genes are known to underlie HSCR risk, with the
Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JB, Hofstra RM, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A.   +24 more
europepmc   +6 more sources

Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner. [PDF]

Oncotarget, 2017
The androgen receptor (AR) is a member of the nuclear receptor superfamily of transcription factors and is central to prostate cancer (PCa) progression. Ligand-activated AR engages androgen response elements (AREs) at androgen-responsive genes to drive the expression of gene batteries involved in cell proliferation and cell fate.
Tam KJ, Dalal K, Hsing M, Cheng CW, Khosravi S, Yenki P, Tse C, Peacock JW, Sharma A, Chiang YT, Wang Y, Cherkasov A, Rennie PS, Gleave ME, Ong CJ.   +14 more
europepmc   +4 more sources

The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. [PDF]

J Biol Chem, 2010
Metastasis is a sequential process that allows cells to move from the primary tumor and grow elsewhere. Because of their ability to cleave a variety of extracellular signaling and adhesion molecules, metalloproteases have been long considered key components of the metastatic program.
Esselens C, Malapeira J, Colomé N, Casal C, Rodríguez-Manzaneque JC, Canals F, Arribas J.   +6 more
europepmc   +4 more sources