Results 11 to 20 of about 4,718 (156)

Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers. [PDF]

Int J Mol Sci, 2019
The semaphorins represent a large family of signaling molecules with crucial roles in neuronal and cardiac development. While normal semaphorin function pertains largely to development, their involvement in malignancy is becoming increasingly evident ...
Hui DHF, Tam KJ, Jiao IZF, Ong CJ.
europepmc   +6 more sources

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. [PDF]

Am J Hum Genet, 2015
Innervation of the gut is segmentally lost in Hirschsprung disease (HSCR), a consequence of cell-autonomous and non-autonomous defects in enteric neuronal cell differentiation, proliferation, migration, or survival.
Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JB, Hofstra RM, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A.   +24 more
europepmc   +8 more sources

A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC) [PDF]

Biomedicines
Background/Objectives: Bladder cancer is a very important issue in contemporary urology. The aim of this pilot study was to assess for the first time the clinical utility of semaphorin 3C (sema3C) and 4A (sema4A) in patients with non-muscle-invasive ...
Piotr Purpurowicz, Tomasz W. Kaminski, Władysław Kordan, Anna Korzekwa, Zbigniew Purpurowicz, Zbigniew Jabłonowski   +5 more
doaj   +3 more sources

A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics.

Nephron, 2023
International audienceBackground: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate ...
Cai A, Placier S, Louedec L, Frère P, Ouchelouche S, Chatziantoniou C, Calmont A.   +6 more
europepmc   +4 more sources

Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity. [PDF]

Nutrients, 2023
International audienceRegular physical activity and the use of nutritional supplements, including antioxidants, are recognized as efficacious approaches for the prevention and mitigation of obesity-related complications.
Supriya R, Shishvan SR, Kefayati M, Abednatanzi H, Razi O, Bagheri R, Escobar KA, Pashaei Z, Saeidi A, Shahrbanian S, Bagchi S, Sengupta P, Al Kiyumi MH, Heinrich KM, Zouhal H.   +14 more
europepmc   +6 more sources

Semaphorin 3C exacerbates liver fibrosis

Hepatology, 2023
Background and Aims: Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-β is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-β signaling during liver fibrosis.
De Angelis Rigotti, Francesca, Wiedmann, Lena, Billeter, Adrian T, Rodriguez-Vita, Juan, Vacca, Margherita, Hasan, Sana S., Moll, Iris, Carvajal, Silvia, Jiménez, Wladimiro, Starostecka, Maja, Hubert, Max Ole   +10 more
core   +6 more sources

The role of Semaphorin 3C in the activation of hepatic stellate cells and liver fibrosis [PDF]

, 2023
Fast 45 % aller Todesfälle in Industrieländern sind auf fibroproliferative Pathologien zurückzuführen, wobei Leberfibrose und in Folge die Leberzirrhose eine der Hauptursachen für diese Todesfälle sind.
Hubert, Max Ole
core   +2 more sources

Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. [PDF]

Diabetologia, 2013
International audienceAIMS/HYPOTHESIS: Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extracellular matrix (ECM) composition, promote an insulin-resistant state.
Esteve, Daniel, Viguerie, N., Lång, P., Bouloumié, A., Wilfling, F. ; https://orcid.org/, Lacasa, D., Esteve, D., Kolditz, C., Mejhert, N., Galitzky, J., Näslund, E., Wilfling, F., Rydén, Mikael, Rydén, M., Clément, K., Kolditz, C.-I., Tordjman, J., Pellegrinelli, V., Trayhurn, P., Dahlman, I., Stich, V., Langin, D.   +21 more
core   +4 more sources

Correlation of Peritumoral Edema and Microvessel Density with Tissue Expression of VEGF, Semaphorins 3A and 3C in Patients with Meningioma

Asian Pacific Journal of Cancer Biology, 2019
Background: Several angiogenic factors correlate with angiogenesis in meningioma while their exact role is yet to be identified. Semaphorins are described with a variety of physiological functions including angiogenesis and migration of neural crest ...
Mehdi Salimi-Sotoodeh, Arash Saffarian, Mousa Taghipour, Amir-Reza Dehghanian, Nooshafarin Chenari, Abbas Ghaderi, Mahboobeh Razmkhah   +6 more
doaj   +4 more sources

Association of Immune Semaphorins with COVID-19 Severity and Outcomes

Biomedicines, 2023
Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic, Neven Papic, Lara Samadan, Mirjana Balen Topic, Adriana Vince   +4 more
doaj   +2 more sources