Results 31 to 40 of about 4,718 (156)
The Expression and Roles of Semaphorin Type 3C in Granulosa Cells during The Luteinization Process [PDF]
Journal of Mammalian Ova Research, 2014 Morphological changes are observed during the luteinization process of granulosa cells, however mechanisms and the roles are remained unclear. In the present study, we demonstrated that Sema3C is expressed in granulosa cells and then secreted to ...
Shimada, Masayuki +4 more
core +4 more sources
The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. [PDF]
J Biol Chem, 2010 Metastasis is a sequential process that allows cells to move from the primary tumor and grow elsewhere. Because of their ability to cleave a variety of extracellular signaling and adhesion molecules, metalloproteases have been long considered key components of the metastatic program.
Esselens C +6 more
europepmc +4 more sources
Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner. [PDF]
Oncotarget, 2017 The androgen receptor (AR) is a member of the nuclear receptor superfamily of transcription factors and is central to prostate cancer (PCa) progression. Ligand-activated AR engages androgen response elements (AREs) at androgen-responsive genes to drive the expression of gene batteries involved in cell proliferation and cell fate.
Tam KJ +14 more
europepmc +4 more sources
Semaphorin 3c (SEMA3C) as a potential therapeutic target in breast cancer
Breast cancer (BCa) is a significant cause of cancer-related deaths among females globally. Approximately 45% of BCa patients develop treatment resistance or suffer from a lack of targeted therapies.
Bhasin, Satyam
core +2 more sources
Semaphorin 3C exacerbates liver fibrosis [PDF]
, 2021 Abstract Background & Aims Chronic liver disease is a growing epidemic leading to fibrosis and cirrhosis. TGF-β is the pivotal pro-fibrogenic cytokine which activates hepatic stellate cells (HSC), yet, other molecules can substantially modulate TGF-β signaling in the course of liver fibrosis ...
Francesca De Angelis Rigotti +16 more
openaire +1 more source
Semaphorin 3C is involved in the progression of gastric cancer. [PDF]
Cancer Sci, 2012 Malignant tumors are often associated with denervation, suggesting the functional implication of axonal guidance molecules in tumor growth. Here, we assessed the role of semaphorin 3C (sema3C) in the progression of gastric cancer. Immunohistochemistry of human samples revealed that sema3C was strongly expressed in neoplastic cells, especially at the ...
Miyato H, Tsuno NH, Kitayama J.
europepmc +4 more sources
Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF-7 breast cancer cells. [PDF]
Oncol Lett, 2017 Previous studies have suggested that semaphorin 3C (SEMA3C) is involved in the tumorigenesis and metastasis of a number of types of cancer. The aim of the present study was to investigate the role of SEMA3C in the proliferation and migration of MCF-7 breast cancer cells.
Zhu X +6 more
europepmc +4 more sources
Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis [PDF]
Cancer Research, 2015 Abstract Semaphorins play important regulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses. We find that semaphorin-3C (sema3C) induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1–dependent manner, while most other ...
Yelena, Mumblat +3 more
openaire +2 more sources
Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma
Journal of International Medical Research, 2021 Objective Semaphorin 3C (Sema3C) may regulate tumor metastasis and prognosis. We determined the biological roles of Sema3C in the hepatic metastasis of gastric adenocarcinoma and evaluated its clinical significance as a potential biomarker.
Maoran Li +6 more
doaj +1 more source