Results 31 to 40 of about 4,625 (132)

Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma

Journal of International Medical Research, 2021
Objective Semaphorin 3C (Sema3C) may regulate tumor metastasis and prognosis. We determined the biological roles of Sema3C in the hepatic metastasis of gastric adenocarcinoma and evaluated its clinical significance as a potential biomarker.
Maoran Li, Danhua Xu, Xiang Xia, Bo Ni, Chunchao Zhu, Gang Zhao, Hui Cao   +6 more
doaj   +1 more source

Genetic inactivation of Semaphorin 3C protects mice from acute kidney injury

Kidney International, 2022
To guide the development of therapeutic interventions for acute kidney injury, elucidating the deleterious pathways of this global health problem is highly warranted. Emerging evidence has indicated a pivotal role of endothelial dysfunction in the etiology of this disease.
Cai, Anxiang, Ye, Guanyu, Placier, Sandrine, Frère, Perrine, Surin, Brigitte, Vandermeersch, Sophie, Kormann, Raphael, Xu-Dubois, Yi-Chun, Genest, Magali, Lannoy, Morgane, Chadjichristos, Christos, Dussaule, Jean-Claude, Scambler, Peter, Chatziantoniou, Christos, Calmont, Amélie   +14 more
openaire   +3 more sources

A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization. [PDF]

PLoS ONE, 2016
In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC)
Shira Toledano, Huayi Lu, Agustina Palacio, Keren Ziv, Ofra Kessler, Shlomit Schaal, Gera Neufeld, Yoreh Barak   +7 more
doaj   +1 more source

Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease

Cell Death and Disease, 2023
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis underlying kidney organization involves complex cell-to-cell interaction ...
Yi-Chun Tsai, Mei-Chuan Kuo, Juan-Chi Huang, Wei-An Chang, Ling-Yu Wu, Yung-Chi Huang, Chao-Yuan Chang, Su-Chu Lee, Ya-Ling Hsu   +8 more
doaj   +1 more source

GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. [PDF]

J Clin Invest, 2006
GATA transcription factors play critical roles in restricting cell lineage differentiation during development. Here, we show that conditional inactivation of GATA-6 in VSMCs results in perinatal mortality from a spectrum of cardiovascular defects, including interrupted aortic arch and persistent truncus arteriosus.
Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS.   +5 more
europepmc   +4 more sources

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

EMBO Molecular Medicine, 2018
Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong   +24 more
doaj   +1 more source

Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe small GTPase Rac1 regulates diverse cellular functions, including both apicobasal and planar cell polarity pathways; however, its role in cardiac outflow tract (OFT) development remains unknown. In the present study, we aimed to examine the
Carmen Leung, Yin Liu, Xiangru Lu, Mella Kim, Thomas A. Drysdale, Qingping Feng   +5 more
doaj   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption [PDF]

Development, 2001
Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3Clocus in mice by targeted mutagenesis. semaphorin 3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac
L, Feiner, A L, Webber, C B, Brown, M M, Lu, L, Jia, P, Feinstein, P, Mombaerts, J A, Epstein, J A, Raper   +8 more
openaire   +2 more sources

Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer

Clinical Epigenetics, 2017
Background The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprogramming for gene expression.
Emilie Evanno, Julie Godet, Nathalie Piccirilli, Joëlle Guilhot, Serge Milin, Jean Marc Gombert, Benoit Fouchaq, Joëlle Roche   +7 more
doaj   +1 more source