Construction and validation of a prognostic signature based on microvascular invasion and immune-related genes in hepatocellular carcinoma [PDF]
Scientific ReportsBackground: Microvascular invasion (MVI) is an independent risk factor of poor prognosis in hepatocellular carcinoma (HCC) and can be used to guide the diagnosis and treatment of HCC.
Hao Li +6 more
doaj +2 more sources
Multimodal Proteomics Reveals Dysregulated Secretion and ECM Remodelling in Schizophrenia Patient iPSC-Derived Astrocytes [PDF]
CellsAstrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear.
Wei-Ping Li +9 more
doaj +2 more sources
LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C [PDF]
Nature Communications, 2021 Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell ...
Luca Ducoli +15 more
doaj +4 more sources
Development, 2012 The wiring of neuronal circuits requires complex mechanisms to guide axon subsets to their specific target with high precision. To overcome the limited number of guidance cues, modulation of axon responsiveness is crucial for specifying accurate trajectories.
Sanyas, Isabelle +3 more
openaire +4 more sources
Semaphorin 3c (SEMA3C) as a potential therapeutic target in breast cancer
Breast cancer (BCa) is a significant cause of cancer-related deaths among females globally. Approximately 45% of BCa patients develop treatment resistance or suffer from a lack of targeted therapies. Previously, we have shown that Semaphorin 3C (SEMA3C) is an autocrine growth factor that drives the growth and treatment resistance of various cancers ...
Bhasin, Satyam
openaire +2 more sources
Single-Cell Transcriptomic Landscape of Cervical Cancer Cell Lines Before and After Chemoradiotherapy [PDF]
CellsCervical cancer remains a significant global health burden, with chemoradioresistance representing a major obstacle to successful treatment. To elucidate the mechanisms underlying this resistance, we established a unique pair of isogenic primary cervical
Dmitriy V. Semenov +5 more
doaj +2 more sources
Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease
Journal of International Medical Research, 2021 Objective Cluster genes, specifically the class 3 semaphorins ( SEMA3 ) including SEMA3C , have been associated with the development of Hirschsprung disease (HSCR) in Caucasian populations.
Gunadi +13 more
doaj +1 more source
Abstract 5348: SEMA3C signaling confers resistance to Wnt Inhibition in glioblastoma
Cancer Research, 2022 Abstract Background: Wnt signaling is widely dysregulated in cancer. The therapeutic potential of Wnt inhibitors appears promising in preclinical studies. However, they have uniformly failed clinical trials. How cancer cells develop Wnt inhibitor resistance is poorly understood. Current Wnt inhibitors are designed targeting either ligand
Jing Hao +6 more
openaire +2 more sources
Association of Immune Semaphorins with COVID-19 Severity and Outcomes
Biomedicines, 2023 Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic +4 more
doaj +1 more source