Results 31 to 40 of about 2,273 (137)
Abstract 5348: SEMA3C signaling confers resistance to Wnt Inhibition in glioblastoma
Cancer Research, 2022 Abstract Background: Wnt signaling is widely dysregulated in cancer. The therapeutic potential of Wnt inhibitors appears promising in preclinical studies. However, they have uniformly failed clinical trials. How cancer cells develop Wnt inhibitor resistance is poorly understood. Current Wnt inhibitors are designed targeting either ligand
Jing Hao +6 more
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Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family [PDF]
Human Genetics, 2021 AbstractDyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and heterogeneous, involving common and rare genetic variation. Multigenerational families segregating apparent monogenic forms of language-related disorders can provide useful entrypoints into ...
Amaia Carrion-Castillo +5 more
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The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair.
PLoS ONE, 2013 Lung diseases characterized by alveolar damage such as bronchopulmonary dysplasia (BPD) in premature infants and emphysema lack efficient treatments. Understanding the mechanisms contributing to normal and impaired alveolar growth and repair may identify
Arul Vadivel +6 more
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EMBO Molecular Medicine, 2015 Retinopathy of prematurity causes visual impairment due to destructive neoangiogenesis after degeneration of the retinal microvasculature. This study was aimed at analyzing whether local delivery of Semaphorin‐3C (Sema3C) suppresses pathological retinal ...
Wan‐Jen Yang +5 more
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Frontiers in Cell and Developmental Biology, 2022 Background: There is accumulating evidence on the clinical importance of the fibroblast growth factor receptor (FGFR) signal, hypoxia, and glycolysis in the immune microenvironment of head and neck squamous cell carcinoma (HNSCC), yet reliable prognostic
Qi Chen +9 more
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Biomedicines, 2022 Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan +5 more
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Scientific Reports, 2022 The transcription factor hepatocyte nuclear factor 1β (HNF-1β) is essential for normal development of the kidney and other epithelial organs. In the developing mouse kidney, HNF-1β is required for the differentiation and patterning of immature nephrons ...
Annie Shao +5 more
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Cell Death and Disease, 2023 Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis underlying kidney organization involves complex cell-to-cell interaction ...
Yi-Chun Tsai +8 more
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Role of Smad4 from ocular surface ectoderm in retinal vasculature development [PDF]
International Journal of Ophthalmology, 2020 "AIM: To investigate how signals from lens regulate retinal vascular development and neovascularization. METHODS: Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.
Jing Li +3 more
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