Results 11 to 20 of about 2,273 (137)

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

Cell Reports, 2014
Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression.
Jianghong Man, Jeremy Rich
exaly   +5 more sources

Integrated bioinformatics analysis of SEMA3C in tongue squamous cell carcinoma using machine-learning strategies

Cancer Cell International
Tongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analysis.
Zhien Feng, Su Yingying, Feng Zhien
exaly   +4 more sources

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer [PDF]

Scientific Reports
FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35 ...
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong   +13 more
doaj   +4 more sources

Dependency of Tamoxifen Sensitive and Resistant ER⁺ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth

Cells, 2023
Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ...
Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong   +6 more
doaj   +3 more sources

Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro [PDF]

Brazilian Journal of Medical and Biological Research, 2018
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling ...
I. Valiulyte, V. Preitakaite, A. Tamasauskas, A. Kazlauskas   +3 more
doaj   +4 more sources

The Role of Immune Semaphorins in Sepsis—A Prospective Cohort Study [PDF]

Microorganisms
In sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival.
Branimir Gjurasin, Lara Samadan Markovic, Leona Radmanic Matotek, Neven Papic   +3 more
doaj   +2 more sources

Construction of a SEMA3 family-based model to predict prognosis and molecular subtypes in pancreatic ductal adenocarcinoma [PDF]

Discover Oncology
Background Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy with a complex tumor microenvironment. Although the class-3 semaphorin (SEMA3) gene family has been implicated in tumor progression and immune regulation, its ...
Xin Jin, Xiao Guan, Yongrun Mu, Min Wang, Chengfeng Wang   +4 more
doaj   +2 more sources

Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

Scientific Reports, 2017
The cardiac neural crest cells (cNCCs) and the second heart field (SHF) play key roles in development of the cardiac outflow tract (OFT) for establishment of completely separated pulmonary and systemic circulations in vertebrates. A neurovascular guiding
Hideyuki Okano, Shinsuke Shibata, Tsutomu Kume   +2 more
exaly   +2 more sources

Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury [PDF]

iScience
Summary: Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated neuroinflammation plays important roles, the underlying mechanism that triggers ...
Junjie Shen, Liangzhi Gong, Yi Sun, Junqing Lin, Wencheng Hu, Jiabao Wei, Xin Miao, Tao Gao, Jinlong Suo, Jia Xu, Yimin Chai, Bingbo Bao, Yun Qian, Xianyou Zheng   +13 more
doaj   +2 more sources

Uncovering endothelial to mesenchymal transition drivers in atherosclerosis via multi-omics analysis [PDF]

BMC Cardiovascular Disorders
Purpose This study aimed to identify novel candidates that regulate Endothelial to mesenchymal transition(EndMT) in atherosclerosis by integrating multi-omics data.
Qingyan Huang, Yuhong Gan, Xiaoqi Zheng, Zhikang Yu, Qionghui Huang, Mingfeng Huang   +5 more
doaj   +2 more sources