A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization [PDF]
PLoS ONE, 2016 In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC)
Shira Toledano +2 more
exaly +8 more sources
Cancer Cell InternationalTongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analysis.
Can Song, Zhien Feng, Yingying Su
exaly +5 more sources
Cells, 2023 Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ...
Satyam Bhasin +6 more
doaj +4 more sources
Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro [PDF]
Brazilian Journal of Medical and Biological Research, 2018 Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling ...
I. Valiulyte +3 more
doaj +6 more sources
Scientific Reports, 2017 The cardiac neural crest cells (cNCCs) and the second heart field (SHF) play key roles in development of the cardiac outflow tract (OFT) for establishment of completely separated pulmonary and systemic circulations in vertebrates. A neurovascular guiding
Kazuki Kodo +2 more
exaly +3 more sources
Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation
Cell Reports, 2014 Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression.
Jianghong Man +9 more
doaj +4 more sources
SEMA 3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1
EMBO Molecular Medicine, 2018 Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock +2 more
exaly +3 more sources
Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury [PDF]
iScienceSummary: Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated neuroinflammation plays important roles, the underlying mechanism that triggers ...
Junjie Shen +13 more
doaj +3 more sources
Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer [PDF]
Scientific ReportsFOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35 ...
Kevin J. Tam +13 more
doaj +4 more sources
Single-Cell RNA Sequencing and Bulk RNA Sequencing Revealed the Interplay Between Intratumoral Heterogeneity and the Tumor Microenvironment in Breast Cancer. [PDF]
Cancer MedThe figure shows single‐cell datasets of breast cancer collected from the GEO database, including estrogen receptor‐positive breast cancer, HER2‐positive breast cancer, and triple‐negative breast cancer. These datasets are used to analyze differences among breast cancer subtypes by studying the interactions among epithelial cells, fibroblasts ...
Zhao Y +6 more
europepmc +2 more sources