Results 41 to 50 of about 2,506 (164)

Semaphorin‐3C signals through Neuropilin‐1 and PlexinD1 receptors to inhibit pathological angiogenesis

EMBO Molecular Medicine, 2015
Retinopathy of prematurity causes visual impairment due to destructive neoangiogenesis after degeneration of the retinal microvasculature. This study was aimed at analyzing whether local delivery of Semaphorin‐3C (Sema3C) suppresses pathological retinal ...
Wan‐Jen Yang, Junhao Hu, Akiyoshi Uemura, Fabian Tetzlaff, Hellmut G Augustin, Andreas Fischer   +5 more
doaj   +1 more source

Investigation of an FGFR-Signaling-Related Prognostic Model and Immune Landscape in Head and Neck Squamous Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: There is accumulating evidence on the clinical importance of the fibroblast growth factor receptor (FGFR) signal, hypoxia, and glycolysis in the immune microenvironment of head and neck squamous cell carcinoma (HNSCC), yet reliable prognostic
Qi Chen, Qi Chen, Qi Chen, Ling Chu, Xinyu Li, Hao Li, Ying Zhang, Qingtai Cao, Quan Zhuang, Quan Zhuang   +9 more
doaj   +1 more source

Intranasal Sema3C siRNA disrupts normal alveolar development.

, 2013
A–B. Immunoblotting showing decreased whole lung Sema3C protein expression with intranasal Sema3C siRNA administration as compared to scrambled siRNA at P14 (n = 3 lungs/group ...
Arul Vadivel (424484), Jennifer J. P. Collins (127090), Farah Eaton (424488), Bernard Thébaud (39221), Megan O’Reilly (424487), Rajesh S. Alphonse (424485), Tim van Haaften (424486)   +6 more
core   +1 more source

Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney

Scientific Reports, 2022
The transcription factor hepatocyte nuclear factor 1β (HNF-1β) is essential for normal development of the kidney and other epithelial organs. In the developing mouse kidney, HNF-1β is required for the differentiation and patterning of immature nephrons ...
Annie Shao, Micah D. Gearhart, Siu Chiu Chan, Zhen Miao, Katalin Susztak, Peter Igarashi   +5 more
doaj   +1 more source

Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?

Biomedicines, 2022
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan, Neven Papić, Maja Mijić, Ivana Knežević Štromar, Slavko Gašparov, Adriana Vince   +5 more
doaj   +1 more source

Role of Smad4 from ocular surface ectoderm in retinal vasculature development [PDF]

International Journal of Ophthalmology, 2020
"AIM: To investigate how signals from lens regulate retinal vascular development and neovascularization. METHODS: Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.
Jing Li, Jin-Song Zhang, Jiang-Yue Zhao, Guo-Ge Han   +3 more
doaj   +1 more source

Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease

Cell Death and Disease, 2023
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis underlying kidney organization involves complex cell-to-cell interaction ...
Yi-Chun Tsai, Mei-Chuan Kuo, Juan-Chi Huang, Wei-An Chang, Ling-Yu Wu, Yung-Chi Huang, Chao-Yuan Chang, Su-Chu Lee, Ya-Ling Hsu   +8 more
doaj   +1 more source

Presence of PlexinA2, Sema3C and myelinated nerves in distal alveoli.

, 2013
A. Representative photomicrographs showing PlexinA2 staining (brown) in RA (room air), RA+Sema3C, hyperoxia (O2) and O2+Sema3C exposed lungs. Arrows highlight PlexinA2-positive cells; scale bars represent 100 µm. B.
Arul Vadivel (424484), Jennifer J. P. Collins (127090), Farah Eaton (424488), Bernard Thébaud (39221), Megan O’Reilly (424487), Rajesh S. Alphonse (424485), Tim van Haaften (424486)   +6 more
core   +1 more source

A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics

, 2022
International audienceBackground: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate ...
Souhila Ouchelouche, Sandrine Placier, Ouchelouche, Souhila, Chatziantoniou, Christos, Louedec, Liliane, Liliane Louedec, Perrine Frère, Frère, Perrine, Placier, Sandrine, Amélie Calmont, Cai, Anxiang, Calmont, Amélie, Christos Chatziantoniou, Anxiang Cai   +13 more
core   +1 more source

Injection of FR-sema3C does not affect retinal morphology.

, 2016
(A) Shown are representative photographs of haematoxylin-eosin stained transverse sections from a retina derived from the eye of a mouse injected with vehicle alone (Control) or from an eye injected with FR-sema3C/Fc after 23 days.
Shira Toledano (3609302), Keren Ziv (359532), Ofra Kessler (270539), Agustina Palacio (3609305), Huayi Lu (424662), Yoreh Barak (3609299), Shlomit Schaal (2936955), Gera Neufeld (270543)   +7 more
core   +1 more source