Results 61 to 70 of about 2,506 (164)
Clinical Epigenetics, 2017 Background The epithelial-to-mesenchymal transition (EMT) enables epithelial cancer cells to acquire mesenchymal features and contributes to metastasis and resistance to treatment. This process involves epigenetic reprogramming for gene expression.
Emilie Evanno +7 more
doaj +1 more source
From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease
Pulmonary Circulation, Volume 16, Issue 2, June 2026.ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley +1 more source
EBioMedicine, 2017 Background: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria and ...
Ismail D. Legason +23 more
doaj +1 more source
A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer
BMC Medical Genomics, 2020 Background Initially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological and developmental functions, including the regulation of immune responses, angiogenesis, organ formation ...
Xiaoli Zhang +4 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Roberta Besio +7 more
wiley +1 more source
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling
Oncogene, 2021 Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around, and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC). Despite widespread recognition of the clinical significance of PNI, the molecular mechanisms are largely unknown.
Lijuan Yin +6 more
openaire +3 more sources
In vivo Sema3C treatment prevents O2-induced apoptosis and restores proliferation.
, 2013 A–B. Immunoblotting showed increased whole lung caspase 3 expression in hyperoxia exposed lungs, which was prevented by Sema3C treatment (n = 3/group ...
Arul Vadivel (424484) +6 more
core +1 more source
A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models
Cancer Science, Volume 117, Issue 3, Page 841-851, March 2026.We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa +16 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Epigenomic dysregulation contributes to Alzheimer's disease (AD) and related tauopathies. Acetyl‐CoA synthetase 2 (ACSS2), a nuclear‐localized metabolic enzyme in neurons, supports histone acetylation and learning‐related gene expression.
Gabor Egervari +10 more
wiley +1 more source
Silencing of Sema3C causes influx of CD68- and myeloperoxidase-positive cells.
, 2013 A. Representative photomicrographs showing immunostaining for CD68 (brown) in the lungs of untreated P14 rats compared to rats treated with intranasal scrambled siRNA and Sema3C siRNA. Arrows highlight CD68-positive cells. Scale bars represent 100 µm. B.
Arul Vadivel (424484) +6 more
core +1 more source