Results 71 to 80 of about 2,273 (137)

A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes

Frontiers in Immunology
IntroductionData on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.MethodsWe performed a genome wide association study (GWAS) to identify genes associated with survival/mortality,
Albert Rosenberger, Rachel E. Crossland, Ralf Dressel, Dieter Kube, Daniel Wolff, Gerald Wulf, Heike Bickeböller, Anne Dickinson, Ernst Holler   +8 more
doaj   +1 more source

Semaphorins: Novel Insights on Their Emerging Multifaceted Roles in the Evolving Landscape of Breast Cancer

Acta Medica Bulgarica
Semaphorins, initially identified as phylogenetically conserved axon guidance molecules, comprise an extracellular signaling protein family involved in various biological events that regulate the development, tissue homeostasis and cancer progression of ...
Popov Ts.
doaj   +1 more source

Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12

Nature Communications
High endothelial venules (HEVs) provide another portal for tumour metastasis. However, whether HEVs and other blood vessels exert different effects on tumour escape remains unknown.
Qidong Xia, Jiayao Pan, Xiaoqi Weng, Shunrong Li, Jiaqian Li, Shijian Song, Jiang Li, Boxuan Zhou, Xinwei Liu, Dong-Ming Kuang, Nu Zhang, Jin Jin, Jinting Liu, Zhen Lin, Shubin Yu, Qionglan Tang, Lijuan Bian, Yunjie Zeng, Yu Shi, Yiqing Zheng, Jian-You Liao, Shouping Xu, Shicheng Su   +22 more
doaj   +1 more source

CCL20-CCR6 axis mediates mucosal-associated invariant T-M2 macrophage crosstalk to drive immune dysregulation in liver cirrhosis

Frontiers in Immunology
IntroductionCirrhosis is the end-stage of chronic liver disease characterized by progressive hepatic fibrosis and persistent immune dysregulation, yet the mechanisms by which immune cell crosstalk drives disease progression remain poorly understood ...
Bochen Chen, Ruoling Li, Shuya Zhang, Yiting Lou, Shuo Zhang, Jiaheng Lou, Jingcheng Zhang, Chuyun Xu, Tao Jiang, Yuanlin Lv   +9 more
doaj   +1 more source

Gliomagenezės proceso reguliatoriaus semaforino Sema3C veikimo molekulinių mechanizmų tyrimai

, 2018
Sema3 baltymų funkciją reguliuoja furino proteazės, kurių atpažįstamas motyvas RxRR aptinkamas semaforinų Sema, PSI ir baziniuose domenuose. Norint nustatyti, kokią svarbą šis furinų kirpimas turi Sema3C funkcijai angiogenezės procesuose, buvo susintetinti ir išgryninti du rekombinantiniai Sema3C variantai, kurie imitavo baltymo 742RNRR745 vietoje ...
openaire   +1 more source

The SOX4-Semaphorin3C axis promotes esophageal adenocarcinoma progression. [PDF]

Cancer Lett
Fnu T, Shi P, Zhang W, Fang Y, Mitani Y, Zhang Y, Gabre J, Ei-Rifai W, Zaika A, Chen Q, Zhu J, Wang TC, Jiang M, Que J.   +13 more
europepmc   +1 more source

Schwann cell derived extracellular vesicles are multifunctional nanotherapeutic mediators for diabetic oral mucosal wound healing. [PDF]

Discov Nano
Xu Z, Qi H, Zhang X, Qu F, Wu Y, Xu C.
europepmc   +1 more source

An Immune-privileged niche mediates immunotherapy resistance in esophageal carcinoma. [PDF]

J Immunother Cancer
Wan L, Li B, Ma T, Wang M, Xie F, Ge H, Xiao Z, Chen X, Meng L, Zhang L, Xie K, Wang Q.   +11 more
europepmc   +1 more source

Sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation, and matrix remodeling in pancreatic cancer. [PDF]

JCI Insight
Sattler AL, Diba P, Hawthorne K, Pelz C, Grieco J, Korzun T, Chong B, Kuykendall MJ, Sears RC, Marks DL, Sherman MH, Zimmers TA, Eksi SE.   +12 more
europepmc   +1 more source

Potential Therapeutic Targets for Neuroblastoma Screened through Mendelian Randomization Analysis. [PDF]

Arch Iran Med
Yang Z, Zhang Y, Wang S.
europepmc   +1 more source