Results 71 to 80 of about 2,506 (164)
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Objective Irinotecan, a standard therapeutic agent for metastatic colorectal cancer (mCRC), often faces significant limitations due to drug resistance, with treatment failure observed in approximately 30%–50% of patients, leading to poor clinical outcomes.
Yi Pan +9 more
wiley +1 more source
In vivo Sema3C treatment prevents O2-induced influx of CD68- and myeloperoxidase expressing cells.
, 2013 A. Representative photomicrographs showing CD68 staining (brown) in RA (room air), RA+Sema3C, hyperoxia (O2) and O2+Sema3C exposed lungs. Arrows highlight CD68-positive cells; scale bars represent 100 µm. B.
Arul Vadivel (424484) +6 more
core +1 more source
eLife, 2020 The establishment of separated pulmonary and systemic circulation in vertebrates, via cardiac outflow tract (OFT) septation, is a sensitive developmental process accounting for 10% of all congenital anomalies.
Jean-François Darrigrand +10 more
doaj +1 more source
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate
Scientific Reports, 2022 The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P) cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of nsCL/P.
Waheed Awotoye +39 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard +4 more
wiley +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes
Abstract During typical neurodevelopment, astrocytes secrete proteins that support neuronal connectivity. This process is disrupted in Rett Syndrome (RTT), a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. While astrocytes typically promote neuron outgrowth, co-culture of RTT astrocytes
Krissy A. Lyon +4 more
openaire +2 more sources
Andrology, Volume 14, Issue 2, Page 555-570, February 2026.Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco +6 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION In Alzheimer's disease (AD), females have higher prevalence and faster progression, but sex‐specific molecular findings in AD are limited. METHODS We comprehensively examined 6162 proteins in cerebrospinal fluid (CSF) from 2496 participants to identify sex‐specific proteomic alteration by CSF amyloid beta (Aβ)42 and phosphorylated
Anh N. Do +17 more
wiley +1 more source
Development of the neurohypophysis: A major neuroendocrine interface
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh +5 more
wiley +1 more source