Cancer Cell International, 2023 Purpose Semaphorins, axon guidance cues in neuronal network formation, have been implicated in cancer progression. We previously identified semaphorin 3 C (SEMA3C) as a secreted protein overexpressed in pancreatic ductal adenocarcinoma (PDAC).
Satoshi Tomizawa +5 more
doaj +2 more sources
Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family [PDF]
Human Genetics, 2021 AbstractDyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and heterogeneous, involving common and rare genetic variation. Multigenerational families segregating apparent monogenic forms of language-related disorders can provide useful entrypoints into ...
Amaia Carrion-Castillo +5 more
core +8 more sources
The Role of Immune Semaphorins in Sepsis—A Prospective Cohort Study [PDF]
MicroorganismsIn sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival.
Branimir Gjurasin +3 more
doaj +2 more sources
Construction of a SEMA3 family-based model to predict prognosis and molecular subtypes in pancreatic ductal adenocarcinoma [PDF]
Discover OncologyBackground Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy with a complex tumor microenvironment. Although the class-3 semaphorin (SEMA3) gene family has been implicated in tumor progression and immune regulation, its ...
Xin Jin +4 more
doaj +2 more sources
The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair.
PLoS ONE, 2013 Lung diseases characterized by alveolar damage such as bronchopulmonary dysplasia (BPD) in premature infants and emphysema lack efficient treatments. Understanding the mechanisms contributing to normal and impaired alveolar growth and repair may identify
Arul Vadivel +6 more
doaj +2 more sources
Neural crest–derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation [PDF]
Journal of Clinical Investigation, 2015 In mammals, the outflow tract (OFT) of the developing heart septates into the base of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and oxygenated left ventricular blood into the systemic circulation. Accordingly, defective OFT septation is a life-threatening condition that can occur in both syndromic and ...
Alice, Plein +6 more
openaire +4 more sources
Uncovering endothelial to mesenchymal transition drivers in atherosclerosis via multi-omics analysis [PDF]
BMC Cardiovascular DisordersPurpose This study aimed to identify novel candidates that regulate Endothelial to mesenchymal transition(EndMT) in atherosclerosis by integrating multi-omics data.
Qingyan Huang +5 more
doaj +2 more sources
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C [PDF]
Advanced ScienceThe color patterns of mammalian fur are determined by melanocytes' ability to respond to and adapt to microenvironmental cues. However, these patterns can be lost following injury or under pathological conditions, and the underlying biological mechanisms
Tingting Li +17 more
doaj +2 more sources
TURKISH JOURNAL OF BIOLOGY, 2019 Metastasis is the main reason for death in breast cancer. Understanding the molecular players in metastasis is crucial for diagnostic and therapeutic purposes. Notch signalling plays an oncogenic role in breast tumorigenesis and is involved in metastasis.
Cansu KÜÇÜKKÖSE +1 more
openaire +5 more sources
Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis. [PDF]
Hum MutatBackground Acute myocardial infarction (AMI) involves complex immune responses and cellular interaction mechanisms. Although the pathogenesis of AMI is now preliminarily understood, there is still a lack of biomarkers that can accurately and rapidly diagnose its disease characteristics. Methods This study analyzed single‐cell RNA sequencing (scRNA‐seq)
Liu Z +5 more
europepmc +2 more sources