Construction and validation of a prognostic signature based on microvascular invasion and immune-related genes in hepatocellular carcinoma [PDF]
Scientific ReportsBackground: Microvascular invasion (MVI) is an independent risk factor of poor prognosis in hepatocellular carcinoma (HCC) and can be used to guide the diagnosis and treatment of HCC.
Hao Li +6 more
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SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1
EMBO Molecular Medicine, 2018 Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock +24 more
doaj +3 more sources
LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C [PDF]
Nature Communications, 2021 Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell ...
Luca Ducoli +15 more
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Single-Cell Transcriptomic Landscape of Cervical Cancer Cell Lines Before and After Chemoradiotherapy [PDF]
CellsCervical cancer remains a significant global health burden, with chemoradioresistance representing a major obstacle to successful treatment. To elucidate the mechanisms underlying this resistance, we established a unique pair of isogenic primary cervical
Dmitriy V. Semenov +5 more
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An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development. [PDF]
Genes CellsFocusing on an OFT‐specific differentially accessible region, in the present study, we defined a distal OFT myocardial enhancer whose activity depends on GATA binding sites. This enhancer provides insight into the mechanisms underlying spatially restricted Sema3c expression involved in OFT development.
Wang Y +5 more
europepmc +2 more sources
Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaXinwei Han, Tang Bufu, Yuhao Ba
exaly +2 more sources
Single-Cell RNA Sequencing and Bulk RNA Sequencing Revealed the Interplay Between Intratumoral Heterogeneity and the Tumor Microenvironment in Breast Cancer. [PDF]
Cancer MedThe figure shows single‐cell datasets of breast cancer collected from the GEO database, including estrogen receptor‐positive breast cancer, HER2‐positive breast cancer, and triple‐negative breast cancer. These datasets are used to analyze differences among breast cancer subtypes by studying the interactions among epithelial cells, fibroblasts ...
Zhao Y +6 more
europepmc +2 more sources
Cancer Cell International, 2023 Purpose Semaphorins, axon guidance cues in neuronal network formation, have been implicated in cancer progression. We previously identified semaphorin 3 C (SEMA3C) as a secreted protein overexpressed in pancreatic ductal adenocarcinoma (PDAC).
Satoshi Tomizawa +5 more
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Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease
Journal of International Medical Research, 2021 Objective Cluster genes, specifically the class 3 semaphorins ( SEMA3 ) including SEMA3C , have been associated with the development of Hirschsprung disease (HSCR) in Caucasian populations.
Gunadi +13 more
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Association of Immune Semaphorins with COVID-19 Severity and Outcomes
Biomedicines, 2023 Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic +4 more
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