Results 141 to 150 of about 4,278 (174)

The Potential Immunomodulatory Roles of Semaphorin 4D in Human Periapical Lesions

Journal of Endodontics, 2023
Semaphorin 4D (SEMA4D) is an important immunoregulator in the development of inflammatory diseases. Currently, the role of SEMA4D in human apical periodontitis remains unclear. This study aims to investigate the expression of SEMA4D and its potential immunomodulatory roles in apical periodontitis.A total of 31 periapical tissues and 6 healthy gingival ...
Yanglin Zeng, Liu Wang, Liu Liu, Mudan Wang, Lixia Yan, Ling Ye, Dongzhe Song, Dingming Huang   +7 more
openaire   +2 more sources

Semaphorins 4A and 4D in chronic inflammatory diseases

Inflammation Research, 2016
Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer.
Svetlana P. Chapoval, Zahava Vadasz, Andrei I. Chapoval, Elias Toubi   +3 more
openaire   +2 more sources

Neurotrophic effect of Semaphorin 4D in PC12 cells

Biochemical and Biophysical Research Communications, 2003
Semaphorins provide crucial attractive and repulsive cues involved in axon guidance during neural development. Out of them, Semaphorin 4D (Sema4D) is enriched in the nervous and immune tissues, and acts as proliferative and survival factors of peripheral lymphocytes in the immune system, but is poorly understood in the nervous system.
Shiho, Fujioka, Kenta, Masuda, Marcia, Toguchi, Yoshiharu, Ohoka, Takayoshi, Sakai, Tatsuo, Furuyama, Shinobu, Inagaki   +6 more
openaire   +2 more sources

Suppression of bone formation by osteoclastic expression of semaphorin 4D

Nature Medicine, 2011
Most of the currently available drugs for osteoporosis inhibit osteoclastic bone resorption; only a few drugs promote osteoblastic bone formation. It is thus becoming increasingly necessary to identify the factors that regulate bone formation. We found that osteoclasts express semaphorin 4D (Sema4D), previously shown to be an axon guidance molecule ...
Takako, Negishi-Koga, Masahiro, Shinohara, Noriko, Komatsu, Haruhiko, Bito, Tatsuhiko, Kodama, Roland H, Friedel, Hiroshi, Takayanagi   +6 more
openaire   +2 more sources

Grb2 mediates semaphorin-4D-dependent RhoA inactivation

Journal of Cell Science, 2012
Summary Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1–ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration.
Tianliang, Sun, Rameshkumar, Krishnan, Jakub M, Swiercz   +2 more
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Receptor Functions of Semaphorin 4D

Biochemistry (Moscow), 2019
Semaphorin 4D (Sema4D) is a multifunctional protein widely expressed in an organism that plays an important role in the control of many physiological and pathological processes, including immunoregulation, neurogenesis, angiogenesis, and tumor progression. It was first described almost 30 years ago and has been actively studied since then.
openaire   +2 more sources

The Semaphorin 4D receptor controls invasive growth by coupling with Met

Nature Cell Biology, 2002
Semaphorins are cell surface and soluble signals that control axonal guidance. Recently, semaphorin receptors (plexins) have been discovered and shown to be widely expressed. Their biological activities outside the nervous system and the signal transduction mechanism(s) they utilize are largely unknown.
Giordano, Silvia, Corso, Simona, Conrotto, Paolo, Artigiani, Stefania, Gilestro, Giorgio, Barberis, Davide, Tamagnone, Luca, Comoglio, Paolo M.   +7 more
openaire   +3 more sources

Semaphorin 4D to suppress bone formation in multiple myeloma.

Journal of Clinical Oncology, 2017
8039 Background: Myeloma bone disease is characterized by osteoclast activation and long-term osteoblast suppression. We investigated if Semaphorin 4D (Sema4D; CD100) plays a role in these processes. Sema4D has been shown to be a potent osteoblast inhibitor (Negishi-Koga T et al, Nat Med. 2011). A study recently identified that the breast cancer cell
Konstantinos Lontos, Juraj Adamik, Peng Zhang, Quanhong Sun, David Roodman, Attaya Suvannasankha, Deborah Lynn Galson   +6 more
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AB0156 Increased Soluble Semaphorin 4D in Rheumatoid Arthritis

Annals of the Rheumatic Diseases, 2014
Background Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder of joints, which characterized with periarticular bone resorption. Recently cross-disciplinary field osteoimmunology was established because of reciprocal interactions between the immune and skeletal systems. To date, it is well known that inflammatory cytokines such as IL-
Y. Yoshida, A. Ogata, T. Tomita, S. Kang, T. Hirano, Y. Shima, M. Narazaki, T. Tanaka, A. Kumanogoh   +8 more
openaire   +1 more source

Semaphorin 4D inhibits collagen synthesis of rat pulp-derived cells

Archives of Oral Biology, 2008
Semaphorins are a group of secreted and membrane-associated molecules that play important roles in axon navigation. Several semaphorin family molecules are expressed in the pharyngeal arches and tooth germs. We analysed the expression of membrane-associated Semaphorin 4D (Sema4D) in tooth germs, and examined its potential role in regulating the ...
Makoto, Abe, Shinobu, Inagaki, Tatsuo, Furuyama, Masahiro, Iwamoto, Satoshi, Wakisaka   +4 more
openaire   +2 more sources