Results 121 to 130 of about 4,062 (156)
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Grb2 mediates semaphorin-4D-dependent RhoA inactivation
Journal of Cell Science, 2012Summary Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1–ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration.
Tianliang, Sun +2 more
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The Semaphorin 4D receptor controls invasive growth by coupling with Met
Nature Cell Biology, 2002Semaphorins are cell surface and soluble signals that control axonal guidance. Recently, semaphorin receptors (plexins) have been discovered and shown to be widely expressed. Their biological activities outside the nervous system and the signal transduction mechanism(s) they utilize are largely unknown.
Giordano, Silvia +7 more
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Semaphorin 4D to suppress bone formation in multiple myeloma.
Journal of Clinical Oncology, 20178039 Background: Myeloma bone disease is characterized by osteoclast activation and long-term osteoblast suppression. We investigated if Semaphorin 4D (Sema4D; CD100) plays a role in these processes. Sema4D has been shown to be a potent osteoblast inhibitor (Negishi-Koga T et al, Nat Med. 2011). A study recently identified that the breast cancer cell
Konstantinos Lontos +6 more
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Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer
Gene, 2020Semaphorins are a group of proteins that are divided into eight subclasses and identified by a conserved Sema domain on their carboxyl terminus. Sema4A, 4C, and 4D are the members of the fourth class of semaphorin family, which are known as membrane semaphorins; however, these molecules can be altered to soluble semaphorins by proteolytic cleavage ...
Misagh Rajabinejad +6 more
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AB0156 Increased Soluble Semaphorin 4D in Rheumatoid Arthritis
Annals of the Rheumatic Diseases, 2014Background Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder of joints, which characterized with periarticular bone resorption. Recently cross-disciplinary field osteoimmunology was established because of reciprocal interactions between the immune and skeletal systems. To date, it is well known that inflammatory cytokines such as IL-
Y. Yoshida +8 more
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Semaphorin 4D inhibits collagen synthesis of rat pulp-derived cells
Archives of Oral Biology, 2008Semaphorins are a group of secreted and membrane-associated molecules that play important roles in axon navigation. Several semaphorin family molecules are expressed in the pharyngeal arches and tooth germs. We analysed the expression of membrane-associated Semaphorin 4D (Sema4D) in tooth germs, and examined its potential role in regulating the ...
Makoto, Abe +4 more
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Low levels of the immunoregulator Semaphorin 4D (CD100) in sera of HIV patients
Clinical Immunology, 2018Semaphorin-4D (CD100), generated by CD4/CD8 T-cells and its receptor on B cells - CD72, play a role in immune regulation. Both have soluble forms - sCD100/sCD72.sCD100 and sCD72 levels were determined by ELISA (MyBioSource, USA).28 chronic HIV patients and 50 matched healthy volunteers participated in our study.
Z, Vadasz +7 more
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Structural basis of semaphorin‐plexin cis interaction
EMBO Journal, 2020Daniel Rozbeský +2 more
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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
Cell, 2019Inés Barroso +2 more
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