Results 101 to 110 of about 4,278 (174)

Microscopic analysis of the subepithelial inflammatory infiltrate and immunohistochemical evaluation of Semaphorin 4D and PD-L1 in oral leukoplakia

, 2023
Εισαγωγή: Μέχρι σήμερα, ο εκτενής χαρακτηρισμός κλινικοπαθολογικών παραμέτρων της λευκοπλακίας του στόματος (ΛΣ), έχει αποκαλύψει ότι ιστοπαθολογικές αλλοιώσεις του επιθηλίου σχετίζονται με τον κίνδυνο κακοήθους εξαλλαγής (ΚΕ).
Theofilou Vasileios-Ionas, Θεοφίλου Βασίλειος-Ιωνάς   +1 more
core  

Functional regulation of semaphorin receptors by proprotein convertases

, 2003
PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation.
Tamagnone, Luca
core   +1 more source

Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D

Blood, 2016
Abstract Multiple myeloma (MM) bone disease (MMBD) is characterized by activation of osteoclasts and suppression of osteoblastic differentiation, with these changes in the bone microenvironment supporting MM cell growth and drug resistance. These complex interactions between MM cells and bone cells are incompletely understood.
Attaya Suvannasankha, Colin D Crean, Douglas R Tompkins, Jesus Delgado-Calle, Teresita M Bellido, G. David Roodman, John M Chirgwin   +6 more
openaire   +1 more source

Semaphorin 4D Enhances Vascular Stabilization by Recruiting SHED Through Endothelial-Derived PDGF-BB

, 2022
Objectives: To investigate the role of soluble Semaphorin 4D (Sema4D) in recruiting stem cells from human exfoliated deciduous teeth (SHED) as mural cells to enhance vessel stabilization.
Dissanayaka, WL, ZHANG, L
core  

Molecular mechanisms related to bone damage in spinal tuberculosis revealed by 4D-label-free proteomics analysis

Frontiers in Cellular and Infection Microbiology
AimsSpinal tuberculosis (STB) is a common form of extrapulmonary tuberculosis (ETB). However, the molecular mechanism of pathological injury in STB remains unclear.
Wenxuan Xiao, Guangling Yang, Guangling Yang, Shuqin Xu, Shu Song, Yuting Tang, Tianyao Zhou, Weili Huang, Lu Zhang, Yutong Gu, Yutong Gu   +10 more
doaj   +1 more source

Single-cell fixed RNA profiling uncovers SEMA4D and LMCD1 as therapeutic targets in a liver fibrosis model

JHEP Reports
Background & Aims: Single-cell fixed RNA profiling (FLEX) is a novel technique that captures RNA expression in frozen tissues at a single-cell resolution.
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Tran Van Bao, Nguyen Thi Ha, Pham Tuan Anh, Hiroko Ikenaga, Hideki Fujii, Kanako Yoshida, Masaru Enomoto, Sawako Uchida-Kobayashi, Hideto Yuasa, Tsutomu Matsubara, Vu Thuong Huyen, Yi Cheng, Ryota Yamagishi, Naoko Ohtani, Daisuke Oikawa, Fuminori Tokunaga, Tatiana Kisseleva, David A. Brenner, Yasuko Iwakiri, Jordi Gracia-Sancho, Norifumi Kawada   +23 more
doaj   +1 more source

Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice. [PDF]

Epilepsy Res, 2023
Adel SS, Clarke VRJ, Evans-Strong A, Maguire J, Paradis S.   +4 more
europepmc   +1 more source

The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways

, 2009
Semaphorins and their receptors, plexins, have emerged as key regulators of various aspects of neuronal development. In contrast to the Plexin-A family, the cellular functions of Plexin-B family proteins in developing neurons are only poorly understood ...
Tamagnone L, Deng, S., Vodrazka, P., Fazzari, P., Kuner, R., Swiercz, J. M., Hirschberg, A., Korostylev, A., Tamagnone, L., Worzfeld, T., Offermanns, S.   +10 more
core   +1 more source

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

, 2007
Semaphorin 4D (sema4D; CD100) is an integral membrane protein and the ligand for two receptors, CD72 and plexin-B1. Soluble sema4D has been shown to evoke angiogenic responses from endothelial cells and impair monocyte migration, but the origin of ...
Laurence Boumsell, Li Zhu, Hitoshi Kikutani, Jie Wu, Marcin Cieslak, Wolfgang Bergmeier, Marcos E. Milla, Lawrence F. Brass, Tamagnone, Luca, Hong Jiang, Atsushi Kumanogoh, Ran Fan, Luca Tamagnone, Denisa D. Wagner, Timothy J. Stalker   +14 more
core   +1 more source

Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis. [PDF]

Int J Mol Sci, 2022
Ishii T, Ruiz-Torruella M, Yamamoto K, Yamaguchi T, Heidari A, Pierrelus R, Leon E, Shindo S, Rawas-Qalaji M, Pastore MR, Ikeda A, Nakamura S, Mawardi H, Kandalam U, Hardigan P, Witek L, Coelho PG, Kawai T.   +17 more
europepmc   +1 more source