Results 111 to 120 of about 4,062 (156)

Saturation monitoring of VX15/2503, a novel semaphorin 4D-specific antibody, in clinical trials. [PDF]

Cytometry B Clin Cytom, 2016
Fisher TL, Seils J, Reilly C, Litwin V, Green L, Salkowitz-Bokal J, Walsh R, Harville S, Leonard JE, Smith E, Zauderer M.   +10 more
europepmc   +1 more source

Semaphorin 4D in human head and neck cancer tissue and peripheral blood: A dense fibrotic peri-tumoral stromal phenotype. [PDF]

Oncotarget, 2018
Derakhshandeh R, Sanadhya S, Lee Han K, Chen H, Goloubeva O, Webb TJ, Younis RH.   +6 more
europepmc   +1 more source

Serum Semaphorin Alterations in Psoriasis: Links to Metabolic Status Rather than Disease Severity. [PDF]

Metabolites
Baran A, Stepaniuk A, Hermanowicz JM, Sieklucka B, Pawlak K, Pawlak D, Flisiak I.   +6 more
europepmc   +1 more source

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Signaling from membrane semaphorin 4D in T lymphocytes

Molecular Immunology, 2021
Semaphorin 4D (Sema4D) is widely represented in the immune system in both membrane and soluble form, and controls immune processes through the specific receptors - these are generally accepted views. Here, an alternative way of Sema4D-dependent immunoregulation is presented, suggesting its functioning as a receptor.
Elena, Kuklina, Irina, Nekrasova, Natalia, Glebezdina   +2 more
openaire   +2 more sources

Semaphorin 4D as a guidance molecule in the immune system

International Reviews of Immunology, 2021
Semaphorin 4D (Sema4D) is a classic member of the semaphorin family involved in axonal guidance processes. The key effects of Sema4D in neurons are mediated by high affinity plexin receptors and are associated with cytoskeleton rearrangement, leading to growth cone collapse or regulation of cell migration.
openaire   +2 more sources

The Potential Immunomodulatory Roles of Semaphorin 4D in Human Periapical Lesions

Journal of Endodontics, 2023
Semaphorin 4D (SEMA4D) is an important immunoregulator in the development of inflammatory diseases. Currently, the role of SEMA4D in human apical periodontitis remains unclear. This study aims to investigate the expression of SEMA4D and its potential immunomodulatory roles in apical periodontitis.A total of 31 periapical tissues and 6 healthy gingival ...
Yanglin Zeng, Liu Wang, Liu Liu, Mudan Wang, Lixia Yan, Ling Ye, Dongzhe Song, Dingming Huang   +7 more
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Semaphorins 4A and 4D in chronic inflammatory diseases

Inflammation Research, 2016
Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer.
Svetlana P. Chapoval, Zahava Vadasz, Andrei I. Chapoval, Elias Toubi   +3 more
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Neurotrophic effect of Semaphorin 4D in PC12 cells

Biochemical and Biophysical Research Communications, 2003
Semaphorins provide crucial attractive and repulsive cues involved in axon guidance during neural development. Out of them, Semaphorin 4D (Sema4D) is enriched in the nervous and immune tissues, and acts as proliferative and survival factors of peripheral lymphocytes in the immune system, but is poorly understood in the nervous system.
Shiho, Fujioka, Kenta, Masuda, Marcia, Toguchi, Yoshiharu, Ohoka, Takayoshi, Sakai, Tatsuo, Furuyama, Shinobu, Inagaki   +6 more
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Suppression of bone formation by osteoclastic expression of semaphorin 4D

Nature Medicine, 2011
Most of the currently available drugs for osteoporosis inhibit osteoclastic bone resorption; only a few drugs promote osteoblastic bone formation. It is thus becoming increasingly necessary to identify the factors that regulate bone formation. We found that osteoclasts express semaphorin 4D (Sema4D), previously shown to be an axon guidance molecule ...
Takako, Negishi-Koga, Masahiro, Shinohara, Noriko, Komatsu, Haruhiko, Bito, Tatsuhiko, Kodama, Roland H, Friedel, Hiroshi, Takayanagi   +6 more
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Receptor Functions of Semaphorin 4D

Biochemistry (Moscow), 2019
Semaphorin 4D (Sema4D) is a multifunctional protein widely expressed in an organism that plays an important role in the control of many physiological and pathological processes, including immunoregulation, neurogenesis, angiogenesis, and tumor progression. It was first described almost 30 years ago and has been actively studied since then.
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